4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester

Base Information

Chemical Name:4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester
CAS No.:1310382-71-8
Molecular Formula:C₃₆H₃₂N₂O₉S
Molecular Weight:668.724
Hs Code.:

4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester

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Chemical Property of 4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester

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Technology Process of 4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester

There total 10 articles about 4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310382-65-0
4-methoxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester

: 1310382-71-8
4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester

Guidance literature:: With boron trichloride; In hexane; dichloromethane; at 0 - 20 ℃; for 3.5h;
DOI:10.1002/ddr.20391

Reference yield:

: 890120-49-7
3-methoxy-4[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2,5-dicarboxylic acid dimethyl ester

: 1310382-71-8
4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide

2: dmap; oxalyl dichloride / 0.33 h / 20 °C

3: diethylaluminium chloride / hexane; dichloromethane / 15 h / 0 - 20 °C

4: boron trichloride / hexane; dichloromethane / 3.5 h / 0 - 20 °C

With dmap; oxalyl dichloride; water; diethylaluminium chloride; boron trichloride; lithium hydroxide; In hexane; dichloromethane;
DOI:10.1002/ddr.20391

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1310382-71-8
4-hydroxy-5-[7-(4-methoxycarbonyl-butyl)-1H-indole-3-carbonyl]-3-[1-(toluene-4-sulfonyl)-1H-indol-3-yl]-furan-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / butanone / Reflux; Inert atmosphere

2: water; lithium hydroxide

3: dmap; oxalyl dichloride / 0.33 h / 20 °C

4: diethylaluminium chloride / hexane; dichloromethane / 15 h / 0 - 20 °C

5: boron trichloride / hexane; dichloromethane / 3.5 h / 0 - 20 °C

With dmap; oxalyl dichloride; water; diethylaluminium chloride; boron trichloride; potassium carbonate; lithium hydroxide; In hexane; dichloromethane; butanone;
DOI:10.1002/ddr.20391