({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium

Base Information

Chemical Name:({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium
CAS No.:1531593-90-4
Molecular Formula:C₆H₁₅N*C₂₇H₃₂FN₇O₈S₂
Molecular Weight:766.915
Hs Code.:

({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium

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Chemical Property of ({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium

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Technology Process of ({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium

There total 7 articles about ({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1531593-88-0
ethyl 4-(2-fluoro-4-{[(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]amino}phenyl)piperazine-1-carboxylate

: 121-44-8
triethylamine

: 957-68-6
7-Aminocephalosporanic acid

: 1531593-90-4
({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1007/s00044-013-0898-4

Reference yield:

: 1531593-73-3
ethyl 4-{4-[(2-ethoxy-2-oxoethyl)amino]-2-fluorophenyl}piperazine-1-carboxylate

: 1531593-90-4
({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 14 h / Reflux

2: potassium hydroxide / ethanol / 13 h / Reflux

3: tetrahydrofuran / 4 h / 20 °C

With hydrazine hydrate; potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1007/s00044-013-0898-4

Reference yield:

: 1531593-74-4
ethyl 4-{2-fluoro-4-[(2-hydrazinyl-2-oxoethyl)amino]phenyl}piperazine-1-carboxylate

: 1531593-90-4
({[(6R,7R)-3-[(acetyloxy)methyl]-7-({[5-[({4-[4-(ethoxycarbonyl)piperazin-1-yl]-3-fluorophenyl}amino)methyl]-2-thioxo-1,3,4-oxadiazol-3(2H)-yl]methyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]carbonyl}oxy)(triethyl)ammonium

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 13 h / Reflux

2: tetrahydrofuran / 4 h / 20 °C

With potassium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1007/s00044-013-0898-4