(1-Naphthyloxy)acetyl chloride

Base Information

• Chemical Name: (1-Naphthyloxy)acetyl chloride
• CAS No.: 2007-12-7
• Molecular Formula: C12H9 Cl O2
• Molecular Weight: 220.65
• Hs Code.: 2918990090
• NSC Number: 158349
• DSSTox Substance ID: DTXSID00303442
• Wikidata: Q82048735
• Mol file: 2007-12-7.mol

Synonyms:(1-naphthyloxy)acetyl chloride;2007-12-7;2-(naphthalen-1-yloxy)acetyl chloride;2-naphthalen-1-yloxyacetyl chloride;NSC158349;Naphthoxy acetic acid chloride;SCHEMBL3253891;DTXSID00303442;ZOORULWLQVVPOJ-UHFFFAOYSA-N;BBL014492;MFCD12025104;AKOS005172532;NSC-158349;FT-0683320;5167-01-1

Chemical Property of (1-Naphthyloxy)acetyl chloride

Chemical Property:

• Vapor Pressure: 9.45E-05mmHg at 25°C
• Boiling Point: 339°C at 760 mmHg
• Flash Point: 125.6°C
• PSA: 26.30000
• Density: 1.278g/cm³
• LogP: 2.98400
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 220.0291072
• Heavy Atom Count: 15
• Complexity: 230

Purity/Quality:

99% ^*data from raw suppliers

(1-naphthyloxy)acetylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2OCC(=O)Cl

Technology Process of (1-Naphthyloxy)acetyl chloride

There total 6 articles about (1-Naphthyloxy)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

→ 2-(1-naphthyloxy)acetyl chloride (2007-12-7)

Guidance literature:

With thionyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 ℃; for 5h;

Reference yield:

1-Naphthoxyacetic acid (2976-75-2) → 2-(1-naphthyloxy)acetyl chloride (2007-12-7)

Guidance literature:

With phosphorus pentachloride; benzene;

Reference yield:

α-naphthol (90-15-3) → 2-(1-naphthyloxy)acetyl chloride (2007-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / aq. KOH / 3 h / Heating

2: oxalyl chloride / benzene / 0.5 h / Heating

With potassium hydroxide; oxalyl dichloride; In benzene;

DOI:10.1021/jm960271d

upstream raw materials:

1-Naphthoxyacetic acid

α-naphthol

ethyl (1-naphthalenyloxy)acetate

Downstream raw materials:

2-(2-chloro-phenyl)-5-(naphthalen-1-yloxy-acetyl)-5H-oxazolo[4,5-b]phenoxazine

N-(2-diethylaminoethyl)-2-(naphthalen-1-yloxy)acetamide

1-Aziridin-1-yl-2-(naphthalen-1-yloxy)-ethanone

C₄₆H₄₀N₂O₆