1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione 3'-O-<(2-Cyanoethyl) N,N-Diisopropylphosphoramidite>

Base Information

• Chemical Name: 1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione 3'-O-<(2-Cyanoethyl) N,N-Diisopropylphosphoramidite>
• CAS No.: 138214-70-7
• Molecular Formula: C₄₃H₅₁N₆O₈P
• Molecular Weight: 810.887

Synonyms:

Chemical Property of 1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione 3'-O-<(2-Cyanoethyl) N,N-Diisopropylphosphoramidite>

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione 3'-O-<(2-Cyanoethyl) N,N-Diisopropylphosphoramidite>

There total 3 articles about 1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione 3'-O-<(2-Cyanoethyl) N,N-Diisopropylphosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione → 1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione 3'-O-<(2-Cyanoethyl) N,N-Diisopropylphosphoramidite> (138214-70-7)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In acetonitrile; for 2h;

DOI:10.1002/hlca.19910740834

Reference yield:

1-(2-deoxy-β-D-erythro-pentofuranosyl)-6,7-dimethyllumazine (35777-72-1) → 1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione 3'-O-<(2-Cyanoethyl) N,N-Diisopropylphosphoramidite> (138214-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / pyridine / 1 h / Ambient temperature

2: 70 percent / diisopropylammonium tetrazolide / acetonitrile / 2 h

With pyridine; N,N-diisopropylamine tetrazolide; In acetonitrile;

DOI:10.1002/hlca.19910740834

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 1-<2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl>-6,7-dimethylpteridine-2,4(1H,3H)-dione 3'-O-<(2-Cyanoethyl) N,N-Diisopropylphosphoramidite> (138214-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / pyridine / 1 h / Ambient temperature

2: 70 percent / diisopropylammonium tetrazolide / acetonitrile / 2 h

With pyridine; N,N-diisopropylamine tetrazolide; In acetonitrile;

DOI:10.1002/hlca.19910740834

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

1-(2-deoxy-β-D-erythro-pentofuranosyl)-6,7-dimethyllumazine

4,4'-dimethoxytrityl chloride

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