(3S,4R)-3-Fluoro-4-piperidinol hydrochloride

Base Information

• Chemical Name: (3S,4R)-3-Fluoro-4-piperidinol hydrochloride
• CAS No.: 1147112-69-3
• Molecular Formula: C₅H₁₀FNO
• Molecular Weight: 119.139
• Mol file: 1147112-69-3.mol

Synonyms:

Chemical Property of (3S,4R)-3-Fluoro-4-piperidinol hydrochloride

Chemical Property:

• Boiling Point: 196.6±40.0 °C(Predicted)
• PKA: 13.79±0.40(Predicted)
• Density: 1.14±0.1 g/cm3(Predicted)

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3S,4R)-3-Fluoropiperidin-4-olHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4R)-3-Fluoro-4-piperidinol hydrochloride

There total 10 articles about (3S,4R)-3-Fluoro-4-piperidinol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (373604-28-5,955029-44-4) → 3-fluoropiperidin-4-ol (373604-29-6,1147112-69-3,955082-98-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

Reference yield: 100.0%

rac cis-3-fluoropiperidin-4-ol hydrochloride (1523530-55-3,1356339-27-9,955028-84-9,955028-89-4) → C5H10FNO (1147112-69-3,955082-98-1)

Guidance literature:

With Macroporous triethylammonium methylpolystyrene carbonate resin; at 20 ℃;

Reference yield:

benzyl cis-3-fluoro-4-hydroxypiperidine-1-carboxylate (913574-95-5,913574-96-6,1554141-63-7) → 3-fluoropiperidin-4-ol (373604-29-6,1147112-69-3,955082-98-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 1h;

upstream raw materials:

tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester

N-tert-butyloxycarbonylpiperidin-4-one

Refernces

• 1、 -. "INDAZOLYL-SPIRO[2.3]HEXANE-CARBONITRILE DERIVATIVES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF". Page/Page column 37. . Retrieved 2019/05/02.
• 2、 Heald, Robert,Bowman, Krista K.,Bryan, Marian C.,Burdick, Daniel,Chan, Bryan,Chan, Emily,Chen, Yuan,Clausen, Saundra,Dominguez-Fernandez, Belen,Eigenbrot, Charles,Elliott, Richard,Hanan, Emily J.,Jackson, Philip,Knight, Jamie,La, Hank,Lainchbury, Michael,Malek, Shiva,Mann, Sam,Merchant, Mark,Mortara, Kyle,Purkey, Hans,Schaefer, Gabriele,Schmidt, Stephen,Seward, Eileen,Sideris, Steve,Shao, Lily,Wang, Shumei,Yeap, Kuen,Yen, Ivana,Yu, Christine,Heffron, Timothy P.. "Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study". supporting information. p. 8877 - 8895. Retrieved 2015/12/08.