1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER
• CAS No.: 373604-28-5
• Molecular Formula: C10H18FNO3
• Molecular Weight: 219.256
• Hs Code.: 2933399090
• Mol file: 373604-28-5.mol

Synonyms:tert-Butyl3-fluoro-4-hydroxypiperidine-1-carboxylate;tert-Butyl 3-fluoro-4-hydroxypiperidinecarboxylate;

Chemical Property of 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• Boiling Point: 300.795 °C at 760 mmHg
• Flash Point: 135.717 °C
• PSA: 49.77000
• Density: 1.156 g/cm³
• LogP: 1.26410
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-Fluoro-4-hydroxy-1-piperidinecarboxylicAcidtert-ButylEster(MixtureofDiastereomers) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Fluoro-4-hydroxy-1-piperidinecarboxylic Acid tert-Butyl Ester is used in the preparation of therapeutic GPR 119 modulators.

Technology Process of 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER

There total 3 articles about 1-PIPERIDINECARBOXYLIC ACID, 3-FLUORO-4-HYDROXY-, 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate (211108-50-8) → 3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (373604-28-5,955029-44-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 4h;

Reference yield:

tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate (211108-48-4) → 3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (373604-28-5,955029-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Selectfluor / acetonitrile / 2 h / 20 °C

2: sodium tetrahydroborate / 2 h / 20 °C

With sodium tetrahydroborate; Selectfluor; In acetonitrile;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 3-fluoro-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester (373604-28-5,955029-44-4)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / N,N-dimethyl-formamide / 24 h / 80 °C

2: Selectfluor / acetonitrile / 2 h / 20 °C

3: sodium tetrahydroborate / 2 h / 20 °C

With sodium tetrahydroborate; Selectfluor; triethylamine; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

tert-butyl-3-fluoro-4-oxopiperidine-1-carboxylate

tert-butyl 4-[(trimethylsilyl)oxy]-3,6-dihydropyridine-1(2H)-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

Downstream raw materials:

(anti)-3-fluoro-4-methanesulfonyloxypiperidine-1-carboxylic acid tert-butyl ester

(trans)-tert-butyl 4-amino-3-fluoropiperidine-1-carboxylate

tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate

(3R,4R)-tert-butyl 4-(benzylamino)-3-fluoropiperidine-1-carboxylate

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