Technology Process of (8-(3-chlorophenyl)-6-hydroxy-[1,2,4]triazolo[1,5-a]pyridine-5-carbonyl)glycine
There total 10 articles about (8-(3-chlorophenyl)-6-hydroxy-[1,2,4]triazolo[1,5-a]pyridine-5-carbonyl)glycine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C15H12ClN3O3; sodium glycinate;
In
2-methoxy-ethanol;
at 100 ℃;
for 0.333333h;
With
hydrogenchloride;
In
ethyl acetate;
DOI:10.1021/acsmedchemlett.7b00404
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: toluene-4-sulfonic acid / toluene / 2.5 h / Reflux; Enzymatic reaction
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 48 h / Reflux
4.1: N,N-dimethyl-formamide / 0.25 h / 130 °C
4.2: 20 °C / Cooling with ice
5.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1 h / -78 °C
5.2: 0.5 h / Cooling
6.1: toluene / 80 °C
7.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; 1,2-dimethoxyethane / 1 h / 100 °C
8.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; methanol / 4 h / 20 °C
9.1: 2-methoxy-ethanol / 0.33 h / 100 °C
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 5%-palladium/activated carbon; hydroxylamine hydrochloride; hydrogen; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; n-heptane; 2-methoxy-ethanol; ethylbenzene; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/acsmedchemlett.7b00404
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; methanol / 4 h / 20 °C
2: 2-methoxy-ethanol / 0.33 h / 100 °C
With
5%-palladium/activated carbon; hydrogen;
In
tetrahydrofuran; methanol; 2-methoxy-ethanol;
DOI:10.1021/acsmedchemlett.7b00404
