(+)-Eseroline

Base Information

Chemical Name:(+)-Eseroline
CAS No.:29347-15-7
Molecular Formula:C₁₃H₁₈N₂O
Molecular Weight:218.299
Hs Code.:
UNII:66D41T0962
Nikkaji Number:J1.556.719H
Wikidata:Q27263994
ChEMBL ID:CHEMBL73782

Synonyms:eseroline;eseroline monohydrochloride, (3aS-cis)-isomer;eseroline, (+)-;eseroline, (3aR-cis)-isomer

Suppliers and Price of (+)-Eseroline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (+)-Eseroline

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:218.141913202
Heavy Atom Count:16
Complexity:296

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC12CCN(C1N(C3=C2C=C(C=C3)O)C)C
Isomeric SMILES:C[C@]12CCN([C@H]1N(C3=C2C=C(C=C3)O)C)C

Technology Process of (+)-Eseroline

There total 15 articles about (+)-Eseroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 29347-10-2
physostigmine

: 29347-15-7,70354-71-1,469-22-7
(+)-Eseroline

Guidance literature:: With sodium hydroxide; In ethanol; for 4h; Ambient temperature;
DOI:10.1021/jm00379a020

Reference yield:

: 104069-12-7
(3aR,8aS)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

: 29347-15-7,70354-71-1,469-22-7
(+)-Eseroline

Guidance literature:: With boron tribromide; In dichloromethane; for 2h; Yield given; Ambient temperature;

Reference yield:

: 153109-50-3
(Z)-2-Methyl-4-triisopropylsilanyloxy-but-2-enoic acid

: 29347-15-7,70354-71-1,469-22-7
(+)-Eseroline

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / DCC, HOBT / tetrahydrofuran / Heating

2: Pd₂(dba)3*CHCl₃, (R)-BINAP, 1,2,2,6,6-pentamethylpiperidine / N,N-dimethyl-acetamide / 1.5 h / 100 °C

3: 3M aq. HCl / tetrahydrofuran / Ambient temperature

4: 1.) Et₃N, MgSO₄, 2.) LiAlH₄ / 1.) THF, RT, overnight, 2.) THF, reflux, 1.5 h

5: BBr₃ / CH₂Cl₂ / 23 °C

With 1,2,2,6,6-pentamethylpiperidine; hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; lithium aluminium tetrahydride; boron tribromide; magnesium sulfate; benzotriazol-1-ol; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/ja980788+