(+)-physostigmine salicylate

Base Information

• Chemical Name: (+)-physostigmine salicylate
• CAS No.: 103957-95-5
• Molecular Formula: C₇H₆O₃*C₁₅H₂₁N₃O₂
• Molecular Weight: 413.473
• Mol file: 103957-95-5.mol

Synonyms:(+)-physostigmine salicylate

Chemical Property of (+)-physostigmine salicylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-physostigmine salicylate

There total 2 articles about (+)-physostigmine salicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl isocyanate (624-83-9) + salicylic acid (69-72-7,25496-36-0,8052-31-1) + (+)-Eseroline (29347-15-7,70354-71-1,469-22-7) → (+)-physostigmine salicylate (103957-95-5)

Guidance literature:

With sodium; Yield given. Multistep reaction; 1.) diethyl ether, r.t., 1.5 min., 2.) 5 min.;

Reference yield:

(3aR,8aS)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole (104069-12-7) → (+)-physostigmine salicylate (103957-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: BBr₃ / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) sodium / 1.) diethyl ether, r.t., 1.5 min., 2.) 5 min.

With sodium; boron tribromide; In dichloromethane;

upstream raw materials:

methyl isocyanate

salicylic acid

(+)-Eseroline

(3aR,8aS)-5-methoxy-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole

Refernces