Technology Process of 5-[(2S,4R)-4-benzyloxypyrrolidin-2-yl]-1H-1,2,3-triazole
There total 6 articles about 5-[(2S,4R)-4-benzyloxypyrrolidin-2-yl]-1H-1,2,3-triazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,4R)-tert-butyl 4-benzyloxy-2-(1H-1,2,3-triazol-5-yl)pyrrolidine-1-carboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.5h;
With
water; sodium hydrogencarbonate;
In
dichloromethane;
for 0.5h;
DOI:10.1002/adsc.201000678
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere
1.2: -20 - 20 °C / Inert atmosphere
2.1: copper(l) iodide; trimethylsilylazide; N-ethyl-N,N-diisopropylamine / methanol; N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
3.2: 0.5 h
With
copper(l) iodide; trimethylsilylazide; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201000678
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 48 h / 20 °C
2.1: diisobutylaluminium hydride / hexane; dichloromethane / -78 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / -20 °C / Inert atmosphere
3.2: -20 - 20 °C / Inert atmosphere
4.1: copper(l) iodide; trimethylsilylazide; N-ethyl-N,N-diisopropylamine / methanol; N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C
5.2: 0.5 h
With
copper(l) iodide; trimethylsilylazide; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201000678
