2-Chloro-N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetamide

Base Information

Chemical Name:2-Chloro-N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetamide
CAS No.:59940-08-8
Molecular Formula:C₁₀H₇Cl₂N₃O₂
Molecular Weight:272.09
Hs Code.:
DSSTox Substance ID:DTXSID801182823

Synonyms:DTXSID801182823;2-Chloro-N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetamide;59940-08-8

Suppliers and Price of 2-Chloro-N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Chloro-N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:270.9915319
Heavy Atom Count:17
Complexity:280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=NN=C(O2)NC(=O)CCl)Cl

Technology Process of 2-Chloro-N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetamide

There total 3 articles about 2-Chloro-N-[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-04-9
chloroacetyl chloride

: 2138-98-9
2-amino-5-(o-chlorophenyl)-1,3,4-oxadiazole

: 59940-08-8
2-chloro-N-[5-(2-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-acetamide

Guidance literature:: In benzene;

Reference yield:

: 89-98-5
2-chloro-benzaldehyde

: 59940-08-8
2-chloro-N-[5-(2-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; potassium carbonate; sodium acetate / methanol; water; 1,4-dioxane / 5 h / 85 °C

2: N,N-dimethyl-formamide / 12 h / 20 °C

With iodine; sodium acetate; potassium carbonate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1080/14756366.2020.1864630

Reference yield:

: 5315-85-5,120445-39-8
2-[(2-chlorophenyl)methylene]hydrazinecarboxamide

: 59940-08-8
2-chloro-N-[5-(2-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: anhydrous Sodium acetate; acetic acid; bromine

2: potassium carbonate / dichloromethane / 10 °C

With bromine; anhydrous Sodium acetate; potassium carbonate; acetic acid; In dichloromethane;
DOI:10.1007/s00044-022-02880-4