Tert-butyl 4-[4-(3,3-dimethylbutyl)anilino]-1-piperidinecarboxylate

Base Information

Chemical Name:Tert-butyl 4-[4-(3,3-dimethylbutyl)anilino]-1-piperidinecarboxylate
CAS No.:241499-53-6
Molecular Formula:C₂₂H₃₆N₂O₂
Molecular Weight:360.54
Hs Code.:
DSSTox Substance ID:DTXSID901134596

Synonyms:241499-53-6;TERT-BUTYL 4-[4-(3,3-DIMETHYLBUTYL)ANILINO]-1-PIPERIDINECARBOXYLATE;tert-Butyl 4-((4-(3,3-dimethylbutyl)phenyl)amino)piperidine-1-carboxylate;tert-butyl 4-{[4-(3,3-dimethylbutyl)phenyl]amino}piperidine-1-carboxylate;SCHEMBL7391257;DTXSID901134596;AS-72272;W13065;tert-butyl 4-[4-(3,3-dimethylbutyl)anilino]piperidine-1-carboxylate;tert-Butyl4-((4-(3,3-dimethylbutyl)phenyl)amino)piperidine-1-carboxylate;1,1-Dimethylethyl 4-[[4-(3,3-dimethylbutyl)phenyl]amino]-1-piperidinecarboxylate

Suppliers and Price of Tert-butyl 4-[4-(3,3-dimethylbutyl)anilino]-1-piperidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Tert-butyl 4-[4-(3,3-dimethylbutyl)anilino]-1-piperidinecarboxylate

Chemical Property:

XLogP3:5.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:360.277678395
Heavy Atom Count:26
Complexity:434

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)CCC1=CC=C(C=C1)NC2CCN(CC2)C(=O)OC(C)(C)C

Technology Process of Tert-butyl 4-[4-(3,3-dimethylbutyl)anilino]-1-piperidinecarboxylate

There total 9 articles about Tert-butyl 4-[4-(3,3-dimethylbutyl)anilino]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[4-(3,3-dimethyl-butyl)-phenylimino]-piperidine-1-carboxylic acid tert-butyl ester

: 241499-53-6
4-[4-(3,3-Dimethyl-butyl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/S0968-0896(00)00077-8

Reference yield:

: 917-92-0
3,3-Dimethylbut-1-yne

: 241499-53-6
4-[4-(3,3-Dimethyl-butyl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / Et₃N; bis(triphenylphosphine) palladium (II) chloride; copper (I) iodide / tetrahydrofuran / 20 °C

2: 94 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 2658.14 Torr

3: TFA / CH₂Cl₂ / 0.5 h

4: CH₂Cl₂ / 0.5 h

5: NaBH(OAc)3 / CH₂Cl₂ / 18 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 1: Arylation / 2: Reduction / 3: Substitution / 4: Condensation / 5: Reduction;
DOI:10.1016/S0968-0896(00)00077-8

Reference yield:

: 159217-89-7
N-Boc-4-iodoaniline

: 241499-53-6
4-[4-(3,3-Dimethyl-butyl)-phenylamino]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / Et₃N; bis(triphenylphosphine) palladium (II) chloride; copper (I) iodide / tetrahydrofuran / 20 °C

2: 94 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 2658.14 Torr

3: TFA / CH₂Cl₂ / 0.5 h

4: CH₂Cl₂ / 0.5 h

5: NaBH(OAc)3 / CH₂Cl₂ / 18 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; 1: Arylation / 2: Reduction / 3: Substitution / 4: Condensation / 5: Reduction;
DOI:10.1016/S0968-0896(00)00077-8