Technology Process of 3-(3-acetamido-2-fluorophenyl)propanoic acid
There total 4 articles about 3-(3-acetamido-2-fluorophenyl)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium hydroxide / toluene / 0 - 25 °C
2: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 25 °C
3: triethylamine; palladium on activated charcoal; hydrogen / methanol / 50 °C / 760.05 Torr
With
palladium on activated charcoal; water; hydrogen; triethylamine; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; methanol; toluene;
1: |Wittig Olefination;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: acetic acid / 2 h / 25 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 0.5 h / -78 °C
3.1: sodium hydroxide / toluene / 0 - 25 °C
4.1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 25 °C
5.1: triethylamine; palladium on activated charcoal; hydrogen / methanol / 50 °C / 760.05 Torr
With
n-butyllithium; palladium on activated charcoal; water; hydrogen; triethylamine; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; methanol; hexane; acetic acid; toluene;
3.1: |Wittig Olefination;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide; water / methanol; tetrahydrofuran / 2 h / 25 °C
2: triethylamine; palladium on activated charcoal; hydrogen / methanol / 50 °C / 760.05 Torr
With
palladium on activated charcoal; water; hydrogen; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol;
