4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester

Base Information

Chemical Name:4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester
CAS No.:867217-61-6
Molecular Formula:C₄₁H₃₃F₅N₄O₈
Molecular Weight:804.727
Hs Code.:

4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester

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Chemical Property of 4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester

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Technology Process of 4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester

There total 8 articles about 4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867217-60-5
2-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-5-iodo-benzoic acid methyl ester

: 201230-82-2
carbon monoxide

: 867217-61-6
4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester

Guidance literature:: With palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;
DOI:10.1016/j.bmcl.2005.07.059

Reference yield:

: 3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenol

: 867217-61-6
4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethylsulfoxide / 70 °C

2: Cs₂CO₃ / dimethylsulfoxide / 80 °C

3: Pd(OAc)2; aq. K₂CO₃ / dimethylformamide / 100 °C

With palladium diacetate; potassium carbonate; caesium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.07.059

Reference yield:

: 415971-53-8
N-(4-methoxybenzyl)-4-phenylbutan-2-amine

: 867217-61-6
4-{3,5-difluoro-4-[(4-methoxy-benzyl)-(1-methyl-3-phenyl-propyl)-amino]-6-[3-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-phenoxy]-pyridin-2-yloxy}-isophthalic acid 3-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: potassium carbonate / dimethylsulfoxide / 70 °C

3: Cs₂CO₃ / dimethylsulfoxide / 80 °C

4: Pd(OAc)2; aq. K₂CO₃ / dimethylformamide / 100 °C

With palladium diacetate; potassium carbonate; caesium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.07.059