isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanamide

Base Information

Chemical Name:isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanamide
CAS No.:131929-38-9
Molecular Formula:C₃₉H₅₄N₆O₆
Molecular Weight:702.894
Hs Code.:

isopropyl (3S,4S)-4-<N-((2R)-3-morpholinocarbonyl-2-(1-naphthylmethyl)propionyl)-L-histidyl>amino-5-cyclohexyl-3-hydroxypentanamide

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Chemical Property of isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanamide

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Technology Process of isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanamide

There total 4 articles about isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98105-43-2
(3S)-3-hydroxy-(4S)-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentanoic acid ethyl ester

: 131929-38-9
isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH

2: N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / ethyl acetate / Ambient temperature

3: 2 N HCl / methanol / 3 h / 60 °C

4: 1) NaOH, 2) HCl, triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / 1) MeOH, 0 deg C, 2 h, stirred, overnight, room temperature 2) MeCN, 0 deg C, after 2 h warmed to ambient temperature, stirred overnight

With hydrogenchloride; sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide; In methanol; ethyl acetate;
DOI:10.1248/cpb.38.2487

Reference yield:

: 98105-45-4
(3S,4S)-4-(N-tert-butoxycarbonyl)amino-5-cyclohexyl-3-hydroxypentanoic acid

: 131929-38-9
isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / ethyl acetate / Ambient temperature

2: 2 N HCl / methanol / 3 h / 60 °C

3: 1) NaOH, 2) HCl, triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / 1) MeOH, 0 deg C, 2 h, stirred, overnight, room temperature 2) MeCN, 0 deg C, after 2 h warmed to ambient temperature, stirred overnight

With hydrogenchloride; sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide; In methanol; ethyl acetate;
DOI:10.1248/cpb.38.2487

Reference yield:

: N-isopropyl (3S,4S)-3-amino-5-cyclohexyl-3-hydroxypentanamide

: 131929-38-9
isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2 N HCl / methanol / 3 h / 60 °C

2: 1) NaOH, 2) HCl, triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide, dicyclohexylcarbodiimide / 1) MeOH, 0 deg C, 2 h, stirred, overnight, room temperature 2) MeCN, 0 deg C, after 2 h warmed to ambient temperature, stirred overnight

With hydrogenchloride; sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide; In methanol;
DOI:10.1248/cpb.38.2487