(S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

Base Information

• Chemical Name: (S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester
• CAS No.: 135721-48-1
• Molecular Formula: C₄₈H₅₆N₆O₁₃
• Molecular Weight: 925.005

Synonyms:

Chemical Property of (S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

There total 7 articles about (S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → (S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester (135721-48-1)

Guidance literature:

Multi-step reaction with 6 steps

1: DCC, 1-hydroxybenzotriazole, NEt₃ / dimethylformamide / 16 h / 4 °C

2: TFA / various solvent(s) / 1 h / Ambient temperature

3: NEt₃, DCC, 1-hydroxybenzotriazole / dimethylformamide / 16 h / 4 °C

4: TFA / various solvent(s) / 1 h / Ambient temperature

5: NEt₃, DCC, 1-hydroxybenzotriazole / dimethylformamide / 16 h / 4 °C

6: TFA / various solvent(s) / 1 h / Ambient temperature

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2463

Reference yield:

Boc-Gly-Lys(Z)-OBzl (37941-56-3) → (S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester (135721-48-1)

Guidance literature:

Multi-step reaction with 7 steps

1: TFA / various solvent(s) / Ambient temperature

2: DCC, 1-hydroxybenzotriazole, NEt₃ / dimethylformamide / 16 h / 4 °C

3: TFA / various solvent(s) / 1 h / Ambient temperature

4: NEt₃, DCC, 1-hydroxybenzotriazole / dimethylformamide / 16 h / 4 °C

5: TFA / various solvent(s) / 1 h / Ambient temperature

6: NEt₃, DCC, 1-hydroxybenzotriazole / dimethylformamide / 16 h / 4 °C

7: TFA / various solvent(s) / 1 h / Ambient temperature

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2463

Reference yield:

(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester (47688-62-0) → (S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester (135721-48-1)

Guidance literature:

Multi-step reaction with 6 steps

1: DCC, 1-hydroxybenzotriazole, NEt₃ / dimethylformamide / 16 h / 4 °C

2: TFA / various solvent(s) / 1 h / Ambient temperature

3: NEt₃, DCC, 1-hydroxybenzotriazole / dimethylformamide / 16 h / 4 °C

4: TFA / various solvent(s) / 1 h / Ambient temperature

5: NEt₃, DCC, 1-hydroxybenzotriazole / dimethylformamide / 16 h / 4 °C

6: TFA / various solvent(s) / 1 h / Ambient temperature

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2463

upstream raw materials:

BOC-L-aspartic acid 4-benzyl ester

Boc-Gly-Lys(Z)-OBzl

(S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

(S)-2-[2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-acetylamino]-6-benzyloxycarbonylamino-hexanoic acid benzyl ester

Downstream raw materials:

Z-Ala-Asp(OBzl)-Ser-Asp(OBzl)-Gly-Lys(Z)-OBzl

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