37941-56-3

Usage

Uses

Used in Pharmaceutical Industry:
Benzyl N-(tert-butoxycarbonyl)glycyl-N~6~-[(benzyloxy)carbonyl]lysinate is used as an intermediate in the production of pharmaceuticals and bioactive molecules. Its ability to selectively protect and modify specific functional groups in peptides makes it an important component in the synthesis of complex peptide structures.
Used in Peptide Chemistry:
Benzyl N-(tert-butoxycarbonyl)glycyl-N~6~-[(benzyloxy)carbonyl]lysinate is used as a building block in the synthesis of peptides with specific amino acid sequences. The protecting groups (Boc and Cbz) allow for the controlled formation of peptide bonds and the incorporation of the glycine and lysine residues into the desired peptide structure.

Upstream product

• 4530-20-5 BOC-glycine 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 6366-70-7 N^ε-carbobenzoxy-L-lysine benzyl ester hydrochloride 
• 24458-14-8 Lys(Z)-OBzl 

Downstream Products

• 131574-46-4 Z-Ala-Asp(OBzl)-Ser-Asp(OBzl)-Gly-Lys(Z)-OBzl 
• 131574-44-2 Z-Asp(OBzl)-Ser-Asp(OBzl)-Gly-Lys(Z)-OBzl 
• 131574-45-3 Boc-Asp(OBzl)-Ser-Asp(OBzl)-Gly-Lys(Z)-OBzl 
• 135721-48-1 (S)-2-(2-{(S)-2-[(S)-2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-3-hydroxy-propionylamino]-3-benzyloxycarbonyl-propionylamino}-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester 
• 131574-42-0 Z-Ser-Asp(OBzl)-Gly-Lys(Z)-OBzl 
• 131574-43-1 Boc-Ser-Asp(OBzl)-Gly-Lys(Z)-OBzl 
• 131574-40-8 Z-Asp(OBzl)-Gly-Lys(Z)-OBzl 
• 135721-45-8 (S)-2-{2-[(S)-2-((S)-2-Amino-3-hydroxy-propionylamino)-3-benzyloxycarbonyl-propionylamino]-acetylamino}-6-benzyloxycarbonylamino-hexanoic acid benzyl ester 
• 131574-41-9 Boc-Asp(OBzl)-Gly-Lys(Z)-OBzl 
• 135721-43-6 (S)-2-[2-((S)-2-Amino-3-benzyloxycarbonyl-propionylamino)-acetylamino]-6-benzyloxycarbonylamino-hexanoic acid benzyl ester 
• 37941-57-4 H-Gly-Lys(Z)-OBzl*TFA 
• 47688-62-0 (S)-2-(2-Amino-acetylamino)-6-benzyloxycarbonylamino-hexanoic acid benzyl ester 

Relevant academic research and scientific papers

The synthesis and immunosuppressive activities of steroid-urotoxin linkers

The urotoxins (Glu-Asp-Gly-OH, His-Gly-Glu-OH, His-Gly-Lys-OH, and His-Gly-Lys-NHNH2) were introduced into the convenient sites of hydrocortisone and prednisolone via the amidation or condensation reactions to form the corresponding linkers 7a-d, 8a-d, 9a,b, and 10a,b in acceptable yields. The bioassays such as prolongation of heterotopic transplanted cardiac tissue survival in vivo, inhibitory effects on phagocytosis of mouse peritoneal macrophages and concanavalin (ConA) or lipopolysaccharide (LPS) induced proliferation of mouse spleen lymphocytes in vitro show that at the comparable concentrations the immunosuppressive activities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b were higher than that of hydrocortisone, prednisolone, and the urotoxins alone, as well as significantly higher than that of the mixture of hydrocortisone and urotoxins or prednisolone and urotoxins. The so-called 'permissive action' may be responsible for the enhancement of the mentioned bioactivities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b.

Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic acid and derivatives thereof, process for their production and use for the production of pharmaceutical agents

Enantiomer-pure compounds of general formulas VIIa and VIIb in which A stands for a group —COO—, and Z and R have different meanings, as well as use thereof are described.