Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester

Base Information

• Chemical Name: Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester
• CAS No.: 95209-65-7
• Molecular Formula: C₁₆H₂₃N₃O₂
• Molecular Weight: 289.378
• Mol file: 95209-65-7.mol

Synonyms:

Chemical Property of Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester

There total 5 articles about Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

heptanal (111-71-7) → Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester (95209-65-7)

Guidance literature:

Multi-step reaction with 6 steps

2: (+) DIPT, Ti(OiPr)4 / various solvent(s) / 18 h / -20 °C

3: TsOH / CH₂Cl₂ / 0.5 h

4: LAH / diethyl ether / 0.5 h / 0 °C

5: 2.) H₂O / 2.) acid

6: PPh₃, DEAD, HN₃ / benzene / 2 h / 20 °C

With titanium(IV) isopropylate; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; tris-(2-chloro-ethyl)-amine; water; triphenylphosphine; diethylazodicarboxylate; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; benzene;

DOI:10.1016/S0040-4039(01)81715-9

Reference yield:

non-1-en-3-ol (21964-44-3,79605-61-1) → Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester (95209-65-7)

Guidance literature:

Multi-step reaction with 5 steps

1: (+) DIPT, Ti(OiPr)4 / various solvent(s) / 18 h / -20 °C

2: TsOH / CH₂Cl₂ / 0.5 h

3: LAH / diethyl ether / 0.5 h / 0 °C

4: 2.) H₂O / 2.) acid

5: PPh₃, DEAD, HN₃ / benzene / 2 h / 20 °C

With titanium(IV) isopropylate; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; tris-(2-chloro-ethyl)-amine; water; triphenylphosphine; diethylazodicarboxylate; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; benzene;

DOI:10.1016/S0040-4039(01)81715-9

Reference yield:

1,2R-epoxy-nonane-3S-ol (79605-69-9) → Benzoic acid (1R,2R)-2-azido-1-methyl-octyl ester (95209-65-7)

Guidance literature:

Multi-step reaction with 4 steps

1: TsOH / CH₂Cl₂ / 0.5 h

2: LAH / diethyl ether / 0.5 h / 0 °C

3: 2.) H₂O / 2.) acid

4: PPh₃, DEAD, HN₃ / benzene / 2 h / 20 °C

With lithium aluminium tetrahydride; tris-(2-chloro-ethyl)-amine; water; triphenylphosphine; diethylazodicarboxylate; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; benzene;

DOI:10.1016/S0040-4039(01)81715-9

upstream raw materials:

heptanal

non-1-en-3-ol

1,2R-epoxy-nonane-3S-ol

(2R,3S)-3-(Tetrahydro-pyran-2-yloxy)-nonan-2-ol

Downstream raw materials:

N-[(R)-1-((R)-1-Hydroxy-ethyl)-heptyl]-benzamide

Erythro-9-(2-hydroxy-3-nonyl)hypoxanthine

9-[(R)-1-((R)-1-Hydroxy-ethyl)-heptyl]-1,9-dihydro-purin-6-one