Technology Process of Erythro-9-(2-hydroxy-3-nonyl)hypoxanthine
There total 12 articles about Erythro-9-(2-hydroxy-3-nonyl)hypoxanthine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium nitrite;
In
acetic acid;
- Guidance literature:
-
Multi-step reaction with 9 steps
2: (+) DIPT, Ti(OiPr)4 / various solvent(s) / 18 h / -20 °C
3: TsOH / CH2Cl2 / 0.5 h
4: LAH / diethyl ether / 0.5 h / 0 °C
5: 2.) H2O / 2.) acid
6: PPh3, DEAD, HN3 / benzene / 2 h / 20 °C
7: 1.) H2O, 2.) H2 / 1.) base, 2.) Pd/C / 2.) EtOH
8: trough oxazoline
9: 2.) H2O
With
titanium(IV) isopropylate; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; tris-(2-chloro-ethyl)-amine; water; hydrogen; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal; toluene-4-sulfonic acid;
In
diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)81715-9
- Guidance literature:
-
Multi-step reaction with 8 steps
1: (+) DIPT, Ti(OiPr)4 / various solvent(s) / 18 h / -20 °C
2: TsOH / CH2Cl2 / 0.5 h
3: LAH / diethyl ether / 0.5 h / 0 °C
4: 2.) H2O / 2.) acid
5: PPh3, DEAD, HN3 / benzene / 2 h / 20 °C
6: 1.) H2O, 2.) H2 / 1.) base, 2.) Pd/C / 2.) EtOH
7: trough oxazoline
8: 2.) H2O
With
titanium(IV) isopropylate; lithium aluminium tetrahydride; L-(+)-diisopropyl tartrate; tris-(2-chloro-ethyl)-amine; water; hydrogen; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal; toluene-4-sulfonic acid;
In
diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)81715-9
