Retinyliden-malonsaeure-mononitril

Base Information

• Chemical Name: Retinyliden-malonsaeure-mononitril
• CAS No.: 1856-68-4
• Molecular Formula: C₂₃H₂₉NO₂
• Molecular Weight: 351.489
• Mol file: 1856-68-4.mol

Synonyms:

Chemical Property of Retinyliden-malonsaeure-mononitril

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Retinyliden-malonsaeure-mononitril

There total 9 articles about Retinyliden-malonsaeure-mononitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

all-trans-Retinal (116-31-4) + cyanoacetic acid (372-09-8) → Retinyliden-malonsaeure-mononitril (1856-68-4,75766-84-6)

Guidance literature:

With piperidine; In benzene; for 5h; Reflux;

DOI:10.1124/mol.114.096560

Reference yield:

(E)-β-ionone (79-77-6,14901-07-6) → Retinyliden-malonsaeure-mononitril (1856-68-4,75766-84-6)

Guidance literature:

Multi-step reaction with 6 steps

1: piperidine / benzene / 18 h / Reflux

2: sulfuric acid; diisobutylaluminium hydride / toluene; water / 1 h / -5 - 0 °C

3: potassium tert-butylate / methanol / 0 - 20 °C

4: piperidine / pyridine / 3 h / Reflux

5: diisobutylaluminium hydride / toluene / 1 h / -5 - 0 °C / Inert atmosphere

6: piperidine / benzene / 5 h / Reflux

With piperidine; sulfuric acid; potassium tert-butylate; diisobutylaluminium hydride; In pyridine; methanol; water; toluene; benzene;

DOI:10.1124/mol.114.096560

Reference yield:

(2E,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienenitrile (5299-98-9) → Retinyliden-malonsaeure-mononitril (1856-68-4,75766-84-6)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid; diisobutylaluminium hydride / toluene; water / 1 h / -5 - 0 °C

2: potassium tert-butylate / methanol / 0 - 20 °C

3: piperidine / pyridine / 3 h / Reflux

4: diisobutylaluminium hydride / toluene / 1 h / -5 - 0 °C / Inert atmosphere

5: piperidine / benzene / 5 h / Reflux

With piperidine; sulfuric acid; potassium tert-butylate; diisobutylaluminium hydride; In pyridine; methanol; water; toluene; benzene;

DOI:10.1124/mol.114.096560

upstream raw materials:

(E)-β-ionone

(2E,4E)-3-methyl-5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-2,4-dienenitrile

(2E,4E)-3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienal

all-trans-Retinal

Downstream raw materials:

β-apo-14'-carotenal