(R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate

Base Information

Chemical Name:(R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate
CAS No.:184592-46-9
Molecular Formula:C₆₆H₅₅NO₁₃S
Molecular Weight:1102.23
Hs Code.:

(R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate

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Chemical Property of (R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate

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Technology Process of (R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate

There total 7 articles about (R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3728-20-9
D-tyrosine methylester hydrochloride

: 184592-46-9
(R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1 N NaOH / CH₂Cl₂ / 2 h

2: aq. KOH / ethanol / 24 h / 60 °C

3: BH₃*THF / tetrahydrofuran / Heating

4: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

5: Et₃N, DMAP / CH₂Cl₂

With dmap; potassium hydroxide; sodium hydroxide; borane-THF; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm960581w

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 184592-46-9
(R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

2: Et₃N, DMAP / CH₂Cl₂

With dmap; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm960581w

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 184592-46-9
(R)-benzyl 2-[(4-{[(3-{4-[(benzyloxycarbonyl)oxy]phenyl}-2-[(phenylsulfonyl)amino]propyl)oxy]carbonyl}-2,6-bis(benzyloxy)phenyl)carbonyl]-3-(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1 N NaOH / CH₂Cl₂ / 2 h

2: aq. KOH / ethanol / 24 h / 60 °C

3: BH₃*THF / tetrahydrofuran / Heating

4: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

5: Et₃N, DMAP / CH₂Cl₂

With dmap; potassium hydroxide; sodium hydroxide; borane-THF; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm960581w