6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester

Base Information

Chemical Name:6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester
CAS No.:220243-99-2
Molecular Formula:C₃₆H₄₇I₄N₅O₁₀
Molecular Weight:1217.41
Hs Code.:

6-azido-2-<i>tert</i>-butoxycarbonylamino-5-{2-<i>tert</i>-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid <i>tert</i>-butyl ester

Synonyms:

Suppliers and Price of 6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester

There total 6 articles about 6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220243-90-3
(2S,5R)-(-)-tert-butyl 2-[(tert-butoxycarbonyl)amino]-6-bromo-5-[O-methoxy-N-(tert-butoxycarbonyl)-L-thyroxinyl]-hexanoate

: 220243-99-2
6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 80 ℃; for 6h;
DOI:10.1016/S0040-4020(98)01023-0

Reference yield:

: 24277-39-2
N-tert-butoxycarbonyl glutamic acid tert-butyl ester

: 220243-99-2
6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 4-N-methylmorpholine / tetrahydrofuran / 0.42 h / 0 °C

2: tetrahydrofuran; diethyl ether / 3 h / 0 °C

3: 5.76 g / aq. HBr / diethyl ether / 0.42 h / -20 °C

4: 77 percent / NaBH₄ / methanol / 3 h / 0 - 20 °C

5: 28 percent / 1,3-dicyclohexyl carbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 16 h / 20 °C

6: NaN₃ / dimethylformamide / 6 h / 80 °C

With 4-methyl-morpholine; dmap; sodium tetrahydroborate; sodium azide; hydrogen bromide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Acylation / 3: Substitution / 4: Reduction / 5: Esterification / 6: Substitution;
DOI:10.1016/S0040-4020(98)01023-0

Reference yield:

: (S)-2-tert-Butoxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid tert-butyl ester

: 220243-99-2
6-azido-2-tert-butoxycarbonylamino-5-{2-tert-butoxycarbonylamino-3-[4-(3,5-diiodo-4-methoxy-phenoxy)-3,5-diiodo-phenyl]-propionyloxy}-hexanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; diethyl ether / 3 h / 0 °C

2: 5.76 g / aq. HBr / diethyl ether / 0.42 h / -20 °C

3: 77 percent / NaBH₄ / methanol / 3 h / 0 - 20 °C

4: 28 percent / 1,3-dicyclohexyl carbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 16 h / 20 °C

5: NaN₃ / dimethylformamide / 6 h / 80 °C

With dmap; sodium tetrahydroborate; sodium azide; hydrogen bromide; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Substitution / 3: Reduction / 4: Esterification / 5: Substitution;
DOI:10.1016/S0040-4020(98)01023-0