3-[(3R,4R)-1-(2-Aminoethyl)-3,4-dimethyl-4-piperidinyl]phenol

Base Information

Chemical Name:3-[(3R,4R)-1-(2-Aminoethyl)-3,4-dimethyl-4-piperidinyl]phenol
CAS No.:220122-51-0
Molecular Formula:C₁₅H₂₄N₂O
Molecular Weight:248.368
Hs Code.:
DSSTox Substance ID:DTXSID201180162

Synonyms:DTXSID201180162;3-[(3R,4R)-1-(2-Aminoethyl)-3,4-dimethyl-4-piperidinyl]phenol;220122-51-0

Suppliers and Price of 3-[(3R,4R)-1-(2-Aminoethyl)-3,4-dimethyl-4-piperidinyl]phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 3-[(3R,4R)-1-(2-Aminoethyl)-3,4-dimethyl-4-piperidinyl]phenol

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:248.188863393
Heavy Atom Count:18
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1CN(CCC1(C)C2=CC(=CC=C2)O)CCN
Isomeric SMILES:C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CCN

Technology Process of 3-[(3R,4R)-1-(2-Aminoethyl)-3,4-dimethyl-4-piperidinyl]phenol

There total 3 articles about 3-[(3R,4R)-1-(2-Aminoethyl)-3,4-dimethyl-4-piperidinyl]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Amino-1-[(3R,4R)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-ethanone

: 220122-51-0
N-(2'-aminoethyl)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; for 3h; Yield given; Heating;

Reference yield:

: 119193-19-0
3-[(3R,4R)-3,4-dimethylpiperidin-4-yl]phenol

: 220122-51-0
N-(2'-aminoethyl)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: BOP, TEA / tetrahydrofuran / 1 h / Ambient temperature

2: CF₃CO₂H / CH₂Cl₂ / -20 - 20 °C

3: BH₃*Me₂S / tetrahydrofuran / 3 h / Heating

With dimethylsulfide borane complex; TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: {2-[(3R,4R)-4-(3-Hydroxy-phenyl)-3,4-dimethyl-piperidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

: 220122-51-0
N-(2'-aminoethyl)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: CF₃CO₂H / CH₂Cl₂ / -20 - 20 °C

2: BH₃*Me₂S / tetrahydrofuran / 3 h / Heating

With dimethylsulfide borane complex; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;