Technology Process of 2-[2-cyclohepta-2,4,6-trienylidene-1-(4-{6-triisopropylsilanyl-3,4-bis-[(triisopropylsilanyl)-ethynyl]-hex-3-ene-1,5-diynyl}-phenyl)-ethylidene]-malononitrile
There total 10 articles about 2-[2-cyclohepta-2,4,6-trienylidene-1-(4-{6-triisopropylsilanyl-3,4-bis-[(triisopropylsilanyl)-ethynyl]-hex-3-ene-1,5-diynyl}-phenyl)-ethylidene]-malononitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 50 percent / methanol; acetic acid / 6 h / 20 °C
2.1: 69 percent / NH4OAc / toluene; acetic acid / 96 h / Heating
3.1: 100 percent / Et3N / CH2Cl2 / 1 h / -78 °C
4.1: Ph3CBF4 / 1,2-dichloro-ethane / 1 h / 80 °C
4.2: Et3N / 1,2-dichloro-ethane; toluene / 1 h / 0 - 20 °C
4.3: 70 percent / 1,2-dichloro-ethane; toluene / 1 h / 80 °C / in dark
5.1: (i-Pr)2NH / [PdCl2(PPh3)2]; CuI / tetrahydrofuran / 11 h / 20 °C
6.1: CH2Cl2 / 25 °C / Irradiation
With
ammonium acetate; trityl tetrafluoroborate; triethylamine; diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid; 1,2-dichloro-ethane; toluene;
DOI:10.1002/1522-2675(20010418)84:4<743::AID-HLCA743>3.0.CO;2-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 69 percent / NH4OAc / toluene; acetic acid / 96 h / Heating
2.1: 100 percent / Et3N / CH2Cl2 / 1 h / -78 °C
3.1: Ph3CBF4 / 1,2-dichloro-ethane / 1 h / 80 °C
3.2: Et3N / 1,2-dichloro-ethane; toluene / 1 h / 0 - 20 °C
3.3: 70 percent / 1,2-dichloro-ethane; toluene / 1 h / 80 °C / in dark
4.1: (i-Pr)2NH / [PdCl2(PPh3)2]; CuI / tetrahydrofuran / 11 h / 20 °C
5.1: CH2Cl2 / 25 °C / Irradiation
With
ammonium acetate; trityl tetrafluoroborate; triethylamine; diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; toluene;
DOI:10.1002/1522-2675(20010418)84:4<743::AID-HLCA743>3.0.CO;2-1
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: BuLi; (i-Pr)2NH / hexane; tetrahydrofuran / 0.25 h / -78 °C
2.1: hexane; tetrahydrofuran / -78 - 0 °C
3.1: BuLi; (i-Pr)2NH / hexane; tetrahydrofuran / 0.25 h / -78 °C
3.2: sat. aq. NH4Cl
4.1: (i-Pr)2NH / [PdCl2(PPh3)2]; CuI / tetrahydrofuran / 11 h / 20 °C
5.1: CH2Cl2 / 25 °C / Irradiation
With
n-butyllithium; diisopropylamine;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/1522-2675(20010418)84:4<743::AID-HLCA743>3.0.CO;2-1