N-carbobenzyloxy-N-methallylglycine

Base Information

• Chemical Name: N-carbobenzyloxy-N-methallylglycine
• CAS No.: 136843-70-4
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.293
• Mol file: 136843-70-4.mol

Synonyms:

Chemical Property of N-carbobenzyloxy-N-methallylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-carbobenzyloxy-N-methallylglycine

There total 1 articles about N-carbobenzyloxy-N-methallylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-3-bromo-1-propene (1458-98-6) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-carbobenzyloxy-N-methallylglycine (136843-70-4)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, 0 deg C, 2.) reflux, 12 h;

DOI:10.3987/COM-90-5626

Reference yield:

N-carbobenzyloxy-N-methallylglycine (136843-70-4) → N-carbobenzyloxy-4-aza-6-methylbicyclo<4.1.0>heptan-2-one (136843-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / diethyl ether

2: diethyl ether / 2 h

3: 57 percent / Cu / benzene / 6 h / Heating

With copper; triethylamine; In diethyl ether; benzene;

DOI:10.3987/COM-90-5626

Reference yield:

N-carbobenzyloxy-N-methallylglycine (136843-70-4) → 1-(N-carbobenzyloxy-N-methallyl)amino-1'-diazopropanone (136843-68-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / diethyl ether

2: diethyl ether / 2 h

With triethylamine; In diethyl ether;

DOI:10.3987/COM-90-5626

upstream raw materials:

2-methyl-3-bromo-1-propene

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

N-carbobenzyloxy-4-aza-6-methylbicyclo<4.1.0>heptan-2-one

1-(N-carbobenzyloxy-N-methallyl)amino-1'-diazopropanone