Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester

Base Information

Chemical Name:Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester
CAS No.:217453-30-0
Molecular Formula:C₂₇H₃₁Cl₂N₃O₇S
Molecular Weight:612.531
Hs Code.:

Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester

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Chemical Property of Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester

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Technology Process of Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester

There total 6 articles about Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192-63-8
1-pyrrolidinecarbonyl chloride

: 425388-74-5
(S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionic acid methyl ester

: 217453-30-0
Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃;
DOI:10.1016/S0960-894X(01)00710-7

Reference yield:

: 705-21-5
3,5-dichlorobenzensulfonyl chloride

: 217453-30-0
Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NEt(iPr)2; DMAP / CH₂Cl₂

2: TFA / CH₂Cl₂ / 20 °C

3: EDC; HOBt; NMM / CH₂Cl₂ / 20 °C

4: TFA / CH₂Cl₂ / 2 h / 0 °C

5: K₂CO₃ / dimethylformamide / 40 °C

With 4-methyl-morpholine; dmap; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00710-7

Reference yield:

: α-methyl proline t-butyl ester

: 217453-30-0
Pyrrolidine-1-carboxylic acid 4-((S)-2-{[(S)-1-(3,5-dichloro-benzenesulfonyl)-2-methyl-pyrrolidine-2-carbonyl]-amino}-2-methoxycarbonyl-ethyl)-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NEt(iPr)2; DMAP / CH₂Cl₂

2: TFA / CH₂Cl₂ / 20 °C

3: EDC; HOBt; NMM / CH₂Cl₂ / 20 °C

4: TFA / CH₂Cl₂ / 2 h / 0 °C

5: K₂CO₃ / dimethylformamide / 40 °C

With 4-methyl-morpholine; dmap; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00710-7