Technology Process of 2,4,6-tri-O-benzoyl-3-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-α-D-galactopyranosyl trichloroacetimidate
There total 5 articles about 2,4,6-tri-O-benzoyl-3-O-(2,3,4,6-tetra-O-benzoyl-β-D-galactopyranosyl)-α-D-galactopyranosyl trichloroacetimidate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 4-dimethylaminopyridine, pyridine / 1 h / Ambient temperature
2: p-TsOH*H2O, 10percent Pd-C / methanol; H2O / 6 h / Heating
3: 1) activated 4A molecular sieves, 2) trimethylsilyl triflate / 1) 1,2-dichloroethane, r.t., 2) toluene, 0 degC, 45 min
4: H2 / 10percent Pd-C / ethyl acetate / 24 h
5: 1,8-diazabicyclo<5,4,0>undec-7-ene / CH2Cl2 / 0.5 h / Ambient temperature
With
pyridine; dmap; palladium on activated charcoal; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; hydrogen; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
methanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/0008-6215(83)85009-5
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 4-dimethylaminopyridine, pyridine / 1 h / Ambient temperature
2: p-TsOH*H2O, 10percent Pd-C / methanol; H2O / 6 h / Heating
3: 1) activated 4A molecular sieves, 2) trimethylsilyl triflate / 1) 1,2-dichloroethane, r.t., 2) toluene, 0 degC, 45 min
4: H2 / 10percent Pd-C / ethyl acetate / 24 h
5: 1,8-diazabicyclo<5,4,0>undec-7-ene / CH2Cl2 / 0.5 h / Ambient temperature
With
pyridine; dmap; palladium on activated charcoal; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; hydrogen; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
methanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/0008-6215(83)85009-5
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) activated 4A molecular sieves, 2) trimethylsilyl triflate / 1) 1,2-dichloroethane, r.t., 2) toluene, 0 degC, 45 min
2: H2 / 10percent Pd-C / ethyl acetate / 24 h
3: 1,8-diazabicyclo<5,4,0>undec-7-ene / CH2Cl2 / 0.5 h / Ambient temperature
With
trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
dichloromethane; ethyl acetate;
DOI:10.1016/0008-6215(83)85009-5
