Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester
CAS No.:152330-90-0
Molecular Formula:C₃₈H₄₈O₈
Molecular Weight:632.794
Hs Code.:

Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester

Synonyms:

Suppliers and Price of Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester

There total 12 articles about Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (1R,3R,4R,5S)-1-((1R,3S)-4-benzyloxy-1,3-dimethyl-2-oxo-butyl)-3,5-dihydroxy-7-(4-methoxy-benzyloxy)-4-methyl-2-methylene-heptyl ester

: 149-73-5
trimethyl orthoformate

: 152330-90-0
Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 25 ℃; for 10h; Yield given;
DOI:10.1016/S0040-4039(00)61619-2

Reference yield:

: 152330-77-3
(2R,3S)-3-hydroxy-N-methoxy-5-(4-methoxybenzyloxy)-N,2-dimethylpentanamide

: 152330-90-0
Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 12 steps

1: imidazole, DMAP / dimethylformamide / 15 h / 25 °C

2: tetrahydrofuran / 2 h / -78 °C

3: 75 percent / aq. K₂CO₃ / tetrahydrofuran / 3 h / 25 °C

4: 96 percent / imidazole / CH₂Cl₂ / 1 h / 25 °C

5: 94 percent / diethyl ether / 0.17 h / -78 °C

6: AcOH, H₂O / tetrahydrofuran / 12 h / 40 °C

7: PPTS / CH₂Cl₂ / 4 h / 25 °C

8: TBAF / tetrahydrofuran / 2 h / 25 °C

9: Dess-Martin periodinane / CH₂Cl₂ / 0.42 h / 25 °C

10: CH₂Cl₂ / 3 h / -78 - -50 °C

11: 95 percent / Et₃N, DMAP / CH₂Cl₂ / 15 h / 25 °C

12: 1.) aq. 0.5 M HCl, 2.) PPTS / 1.) THF, 25 deg C, 6-10 h, 2.) MeOH, 25 deg C, 8 h

With 1H-imidazole; hydrogenchloride; dmap; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; potassium carbonate; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)79360-9

Reference yield:

: 152330-78-4
(2R,3S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2-methyl-pentanoic acid methoxy-methyl-amide

: 152330-90-0
Benzoic acid (2S,3R,4R,6R)-2-((S)-2-benzyloxy-1-methyl-ethyl)-6-[(1R,2S)-2-hydroxy-4-(4-methoxy-benzyloxy)-1-methyl-butyl]-2-methoxy-3-methyl-5-methylene-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 11 steps

1: tetrahydrofuran / 2 h / -78 °C

2: 75 percent / aq. K₂CO₃ / tetrahydrofuran / 3 h / 25 °C

3: 96 percent / imidazole / CH₂Cl₂ / 1 h / 25 °C

4: 94 percent / diethyl ether / 0.17 h / -78 °C

5: AcOH, H₂O / tetrahydrofuran / 12 h / 40 °C

6: PPTS / CH₂Cl₂ / 4 h / 25 °C

7: TBAF / tetrahydrofuran / 2 h / 25 °C

8: Dess-Martin periodinane / CH₂Cl₂ / 0.42 h / 25 °C

9: CH₂Cl₂ / 3 h / -78 - -50 °C

10: 95 percent / Et₃N, DMAP / CH₂Cl₂ / 15 h / 25 °C

11: 1.) aq. 0.5 M HCl, 2.) PPTS / 1.) THF, 25 deg C, 6-10 h, 2.) MeOH, 25 deg C, 8 h

With 1H-imidazole; hydrogenchloride; dmap; tetrabutyl ammonium fluoride; water; pyridinium p-toluenesulfonate; potassium carbonate; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)79360-9