trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester

Base Information

Chemical Name:trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester
CAS No.:868668-33-1
Molecular Formula:C₂₆H₄₁F₃O₇SSi
Molecular Weight:582.754
Hs Code.:

trifluoro-methanesulfonic acid 2-[2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2<i>H</i>-pyran-3-yl ester

Synonyms:

Suppliers and Price of trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester

There total 18 articles about trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868668-31-9
(2R,6S)-2-[2-(tert-butyldimethylsilyloxy)ethyl]-6-[(2R)-3-(p-methoxybenzyloxy)-2-methylpropyl]tetrahydropyran-3-one

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 868668-33-1
trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester

Guidance literature:: (2R,6S)-2-[2-(tert-butyldimethylsilyloxy)ethyl]-6-[(2R)-3-(p-methoxybenzyloxy)-2-methylpropyl]tetrahydropyran-3-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -80 ℃; for 1.5h;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at 0 ℃; for 28h;
DOI:10.1248/cpb.53.989

Reference yield:

: 868668-36-4
(4S,6R)-7-(p-methoxybenzyloxy)-6-methyl-1,4-heptanediol

: 868668-33-1
trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 16 steps

1.1: 93 percent / imidazole / dimethylformamide / 20 °C

2.1: NaH; 15-crown-5 / tetrahydrofuran / 0.5 h / 0 °C

2.2: 96 percent / tetrahydrofuran / 20 °C

3.1: 93 percent / TBAF / tetrahydrofuran / 20 °C

4.1: 91 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

5.1: 95 percent / oxone / dimethylformamide / 0 °C

6.1: ClCO₂Et; Et₃N / tetrahydrofuran / 0.5 h / 0 °C

6.2: 85 percent / tetrahydrofuran; diethyl ether / 20 °C

7.1: 80 percent / copper(II) hexafluoroacetylacetonate / tetrahydrofuran; CH₂Cl₂ / 4 h / Heating

8.1: 98 percent / NaBH₄ / ethanol / 20 °C

9.1: 97 percent / imidazole / dimethylformamide / 20 °C

10.1: N-methylmorpholine N-oxide; aq. OsO₄ / tetrahydrofuran / 1.5 h / 20 °C

11.1: 240 mg / aq. NaIO₄ / tetrahydrofuran / 20 °C

12.1: 99 percent / NaBH₄ / ethanol / 20 °C

13.1: 97 percent / TBAF / tetrahydrofuran / 20 °C

14.1: 91 percent / imidazole / dimethylformamide / 0.17 h / 20 °C

15.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

16.1: lithium hexamethyldisilazide / tetrahydrofuran / 1.5 h / -80 °C

16.2: tetrahydrofuran / 28 h / 0 °C

With 1H-imidazole; Oxone; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; copper(II) hexafluoro-2,4-pentanedionate; 15-crown-5; tetrabutyl ammonium fluoride; chloroformic acid ethyl ester; sodium hydride; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.989

Reference yield:

: 868668-38-6
(4S,6R)-4-allyloxy-7-(p-methoxybenzyloxy)-6-methyl-1-heptanal

: 868668-33-1
trifluoro-methanesulfonic acid 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-[3-(4-methoxy-benzyloxy)-2-methyl-propyl]-5,6-dihydro-2H-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 95 percent / oxone / dimethylformamide / 0 °C

2.1: ClCO₂Et; Et₃N / tetrahydrofuran / 0.5 h / 0 °C

2.2: 85 percent / tetrahydrofuran; diethyl ether / 20 °C

3.1: 80 percent / copper(II) hexafluoroacetylacetonate / tetrahydrofuran; CH₂Cl₂ / 4 h / Heating

4.1: 98 percent / NaBH₄ / ethanol / 20 °C

5.1: 97 percent / imidazole / dimethylformamide / 20 °C

6.1: N-methylmorpholine N-oxide; aq. OsO₄ / tetrahydrofuran / 1.5 h / 20 °C

7.1: 240 mg / aq. NaIO₄ / tetrahydrofuran / 20 °C

8.1: 99 percent / NaBH₄ / ethanol / 20 °C

9.1: 97 percent / TBAF / tetrahydrofuran / 20 °C

10.1: 91 percent / imidazole / dimethylformamide / 0.17 h / 20 °C

11.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 °C

12.1: lithium hexamethyldisilazide / tetrahydrofuran / 1.5 h / -80 °C

12.2: tetrahydrofuran / 28 h / 0 °C

With 1H-imidazole; Oxone; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; copper(II) hexafluoro-2,4-pentanedionate; tetrabutyl ammonium fluoride; chloroformic acid ethyl ester; Dess-Martin periodane; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.53.989