(R,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester

Base Information

Chemical Name:(R,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester
CAS No.:872877-31-1
Molecular Formula:C₄₇H₅₁Cl₂IN₄O₁₁
Molecular Weight:1045.75
Hs Code.:

(R,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester

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Chemical Property of (R,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester

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Technology Process of (R,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester

There total 2 articles about (R,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 872877-33-3
2-benzyloxycarbonylamino-3-[6-(5-{[2-tert-butoxycarbonylamino-2-(3,5-dichloro-4-hydroxy-phenyl)-acetylamino]-methoxycarbonyl-methyl}-3-iodo-2-methoxy-phenyl)-1H-indol-3-yl]-propionic acid tert-butyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 872877-31-1
(R,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester

Guidance literature:: In methanol; benzene; at 20 ℃; for 1.5h;
DOI:10.1248/cpb.53.1277

Reference yield:

: (R,R)-2-{3-[3-(tert-butoxycarbonyl-2-carbobenzyloxyaminoethyl)indol-6-yl]-4-iodo-5-methoxyphenyl}-2-methoxycarbonylmethylammonium p-toluenesulfonate

: 191542-08-2
methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate

: 872877-31-1
(R,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester

: (S,R,R)-3-[6-(5-{1-[2-(3,5-dichloro-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacetylamino]-1-methoxycarbonylmethyl}-3-iodo-2-methoxyphenyl)indol-3-yl]-2-carbobenzyloxyaminopropionic acid tert-butyl ester

Guidance literature:: methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate; With lithium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 0.666667h;

(R,R)-2-{3-[3-(tert-butoxycarbonyl-2-carbobenzyloxyaminoethyl)indol-6-yl]-4-iodo-5-methoxyphenyl}-2-methoxycarbonylmethylammonium p-toluenesulfonate; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; at 0 ℃; for 2.5h;
DOI:10.1248/cpb.53.1277