methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate

Base Information

• Chemical Name: methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate
• CAS No.: 191542-08-2
• Molecular Formula: C₁₅H₁₉Cl₂NO₅
• Molecular Weight: 364.226

Synonyms:methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate

Chemical Property of methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate

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Technology Process of methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate

There total 10 articles about methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate (191542-15-1) + methyl iodide (74-88-4) → methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate (191542-08-2)

Guidance literature:

With sodium hydrogencarbonate; In acetone; for 24h; Heating;

DOI:10.1055/s-1997-1234

Reference yield: 92.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-(3,5-dichloro-4-methoxy)phenylglycine methyl ester hydrochloride → methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate (191542-08-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.3987/COM-99-8514

Reference yield: 92.0%

di-tert-butyl dicarbonate (24424-99-5) + (R)-Amino-(3,5-dichloro-4-methoxy-phenyl)-acetic acid methyl ester (193073-58-4) → methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-methoxyphenyl)acetate (191542-08-2)

Guidance literature:

With triethylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4039(97)00938-6

upstream raw materials:

di-tert-butyl dicarbonate

(R)-Amino-(3,5-dichloro-4-methoxy-phenyl)-acetic acid methyl ester

methyl (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate

methyl iodide

Downstream raw materials:

(R)-Amino-(3,5-dichloro-4-methoxy-phenyl)-acetic acid methyl ester

N-(tert-butoxycarbonyl)-(R)-(3,5-dichloro-4-methoxy)phenylglycine

tert-butoxycarbonylamino-(3,5-dichloro-4-methoxy-phenyl)-acetic acid benzyl ester

[2-{(R)-[tert-butoxycarbonylamino-(3,5-dichloro-4-methoxyphenyl)acetyl]methylamino}-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester

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