(3S^*,4R^*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R^*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2'-methylsulfonyloxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one

Base Information

• Chemical Name: (3S^*,4R^*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R^*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2'-methylsulfonyloxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one
• CAS No.: 88140-05-0
• Molecular Formula: C₄₈H₄₂N₃O₁₅PS
• Molecular Weight: 963.912

Synonyms:

Chemical Property of (3S^*,4R^*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R^*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2'-methylsulfonyloxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one

Chemical Property:

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Safty Information:

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MSDS Files:

Useful:

Technology Process of (3S^*,4R^*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R^*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2'-methylsulfonyloxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one

There total 9 articles about (3S^*,4R^*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R^*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2'-methylsulfonyloxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-furan-2-carboxylic acid (585-70-6) → (3S*,4R*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2'-methylsulfonyloxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one (88140-05-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 2.5 N NaOH / methanol; H₂O / 5 h / Ambient temperature

2: 67.3 percent / dimethylformamide / 24 h

4: 1) n-BuLi, Mg, 1,2-dibromomethane

5: 50 percent / conc HCl / methanol; tetrahydrofuran / 2.5 h / Ambient temperature

6: Et₃N / CH₂Cl₂ / 0 deg C, 0.5 h, RT, overnight

With hydrogenchloride; sodium hydroxide; n-butyllithium; 1,2-dibromomethane; magnesium; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)92147-7

Reference yield:

methyl 5-bromo-2-furoate (2527-99-3) → (3S*,4R*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2'-methylsulfonyloxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one (88140-05-0)

Guidance literature:

Multi-step reaction with 4 steps

2: 1) n-BuLi, Mg, 1,2-dibromomethane

3: 50 percent / conc HCl / methanol; tetrahydrofuran / 2.5 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 0 deg C, 0.5 h, RT, overnight

With hydrogenchloride; n-butyllithium; 1,2-dibromomethane; magnesium; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0040-4020(01)92147-7

Reference yield:

((5-bromofuran-2-yl)methoxy)(tert-butyl)dimethylsilane (88139-93-9) → (3S*,4R*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2'-methylsulfonyloxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one (88140-05-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) n-BuLi, Mg, 1,2-dibromomethane

2: 50 percent / conc HCl / methanol; tetrahydrofuran / 2.5 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 0 deg C, 0.5 h, RT, overnight

With hydrogenchloride; n-butyllithium; 1,2-dibromomethane; magnesium; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/S0040-4020(01)92147-7

upstream raw materials:

methanesulfonyl chloride

(3S^*,4R^*)-1-(o-nitrobenzyloxycarbonyltriphenylphosphoranylidene)methyl-3-<(R^*)-1-(o-nitrobenzyloxycarbonyloxy)ethyl>-4-(2-hydroxymethyl-5'-furanylcarbonyl)methyl-azetidin-2-one

5-bromo-furan-2-carboxylic acid

methyl 5-bromo-2-furoate

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