(S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester
CAS No.:262278-34-2
Molecular Formula:C₃₁H₄₀N₄O₉S
Molecular Weight:644.746
Hs Code.:

(S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester

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Chemical Property of (S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester

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Technology Process of (S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester

There total 7 articles about (S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1121-78-4
5-Hydroxy-2-methylpyridine

: 262278-34-2
(S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: NaH / ammonium chloride; dimethyl sulfoxide

2: m-chloroperoxybenzoic acid; acetic anhydride / methanol; dichloromethane; sodium hydrogencarbonate; acetone

3: manganese dioxide; potassium carbonate / methanol; dichioromethane; dichloromethane

4: PTSA / tetrahydrofuran; NaH; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; ethyl acetate

5: palladium-carbon / 1,4-dioxane; methanol

6: caesium carbonate / ethyl acetate; N,N-dimethyl-formamide

7: tetrahydrofuran; LiOH monohydrate; water

8: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 2,3,5-trimethyl-pyridine; ethyl acetate; N,N-dimethyl-formamide

With manganese dioxide; m-chloroperoxybenzoic acid; NaH; acetic anhydride; potassium carbonate; caesium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; PTSA; palladium-carbon; In tetrahydrofuran; 1,4-dioxane; 2,3,5-trimethyl-pyridine; methanol; dichioromethane; NaH; LiOH monohydrate; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; ammonium chloride; water; sodium hydrogencarbonate; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 63793-98-6
5-benzyloxy-2-methyl-pyridine

: 262278-34-2
(S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: m-chloroperoxybenzoic acid; acetic anhydride / methanol; dichloromethane; sodium hydrogencarbonate; acetone

2: manganese dioxide; potassium carbonate / methanol; dichioromethane; dichloromethane

3: PTSA / tetrahydrofuran; NaH; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; ethyl acetate

4: palladium-carbon / 1,4-dioxane; methanol

5: caesium carbonate / ethyl acetate; N,N-dimethyl-formamide

6: tetrahydrofuran; LiOH monohydrate; water

7: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 2,3,5-trimethyl-pyridine; ethyl acetate; N,N-dimethyl-formamide

With manganese dioxide; m-chloroperoxybenzoic acid; acetic anhydride; potassium carbonate; caesium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; PTSA; palladium-carbon; In tetrahydrofuran; 1,4-dioxane; 2,3,5-trimethyl-pyridine; methanol; dichioromethane; NaH; LiOH monohydrate; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; sodium hydrogencarbonate; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 59781-10-1
2-acetoxymethyl-5-benzyloxy pyridine

: 262278-34-2
(S)-2-benzenesulfonylamino-3-{[7-(3-tert-butoxycarbonylamino-propoxy)-4-oxo-4H-quinolizine-2-carbonyl]-amino}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: manganese dioxide; potassium carbonate / methanol; dichioromethane; dichloromethane

2: PTSA / tetrahydrofuran; NaH; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; ethyl acetate

3: palladium-carbon / 1,4-dioxane; methanol

4: caesium carbonate / ethyl acetate; N,N-dimethyl-formamide

5: tetrahydrofuran; LiOH monohydrate; water

6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / 2,3,5-trimethyl-pyridine; ethyl acetate; N,N-dimethyl-formamide

With manganese dioxide; potassium carbonate; caesium carbonate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; PTSA; palladium-carbon; In tetrahydrofuran; 1,4-dioxane; 2,3,5-trimethyl-pyridine; methanol; dichioromethane; NaH; LiOH monohydrate; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;