[(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester
CAS No.:1026549-67-6
Molecular Formula:C₄₅H₆₆N₈O₁₀
Molecular Weight:879.067
Hs Code.:

[(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of [(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

There total 7 articles about [(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1026549-67-6
[(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: HOBt, DCC, NEt₃ / dimethylformamide / 13 h / 0 - 20 °C

2: 95percent aq. TFA / 0.5 h

3: HOBt, DCC, NEt₃ / dimethylformamide / 13 h / 0 - 20 °C

4: 95percent aq. TFA / 0.5 h

5: 1.) 1,3-diisopropylcarbodiimide, HOBt, 2.) aq. TFA, Et₃SiH / 1.) 1 h, 2.) RT, 1 h

With triethylsilane; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; diisopropyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm950490j

Reference yield:

: 2756-85-6
1-aminocyclohexane carboxylic acid

: 1026549-67-6
[(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: dichlorosulfoxide / methanol / 1.) RT, 3 h, 2.) reflux, 4 h

2: HOBt, DCC, NEt₃ / dimethylformamide / 13 h / 0 - 20 °C

3: 95percent aq. TFA / 0.5 h

4: HOBt, DCC, NEt₃ / dimethylformamide / 13 h / 0 - 20 °C

5: 95percent aq. TFA / 0.5 h

6: 1.) 1,3-diisopropylcarbodiimide, HOBt, 2.) aq. TFA, Et₃SiH / 1.) 1 h, 2.) RT, 1 h

With triethylsilane; thionyl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; diisopropyl-carbodiimide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950490j

Reference yield:

: 37993-32-1
1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride

: 1026549-67-6
[(S)-1-{(R)-1-[(S)-1-(1-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propylcarbamoyl}-cyclohexylcarbamoyl)-2-phenyl-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: HOBt, DCC, NEt₃ / dimethylformamide / 13 h / 0 - 20 °C

2: 95percent aq. TFA / 0.5 h

3: HOBt, DCC, NEt₃ / dimethylformamide / 13 h / 0 - 20 °C

4: 95percent aq. TFA / 0.5 h

5: 1.) 1,3-diisopropylcarbodiimide, HOBt, 2.) aq. TFA, Et₃SiH / 1.) 1 h, 2.) RT, 1 h

With triethylsilane; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; diisopropyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm950490j