Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Base Information

Chemical Name:Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester
CAS No.:107905-15-7
Molecular Formula:C₄₁H₃₉N₃O₁₂
Molecular Weight:765.774
Hs Code.:

Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

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Chemical Property of Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

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Technology Process of Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

There total 3 articles about Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 107905-15-7,115929-70-9
Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / pyridine, (i-Pr)2EtN / 3 h / 40 °C

2: 61 percent / pyridine, 4-(dimethylamino)pyridine / 70 h / 40 °C

3: N,N-dicyclocarbodiimide, pyridine / dioxane / 2 h / Ambient temperature

With pyridine; dmap; N,N-dicyclocarbodiimide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1002/hlca.19910740408

Reference yield:

: 40615-39-2,104766-16-7,131607-26-6,131607-27-7,112501-53-8
1-((2R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)- dione

: 107905-15-7,115929-70-9
Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / pyridine, 4-(dimethylamino)pyridine / 70 h / 40 °C

2: N,N-dicyclocarbodiimide, pyridine / dioxane / 2 h / Ambient temperature

With pyridine; dmap; N,N-dicyclocarbodiimide; In 1,4-dioxane;
DOI:10.1002/hlca.19910740408

Reference yield:

: 16053-52-4,28854-96-8,3545-96-8,50-88-4
threothymidine

: 107905-15-7,115929-70-9
Succinic acid (2R,3R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / pyridine, (i-Pr)2EtN / 3 h / 40 °C

2: 61 percent / pyridine, 4-(dimethylamino)pyridine / 70 h / 40 °C

3: N,N-dicyclocarbodiimide, pyridine / dioxane / 2 h / Ambient temperature

With pyridine; dmap; N,N-dicyclocarbodiimide; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane;
DOI:10.1002/hlca.19910740408