C₅₀H₆₄N₉O₁₅S₃^(1-)*Na⁽¹⁺⁾

Base Information

• Chemical Name: C₅₀H₆₄N₉O₁₅S₃^(1-)*Na⁽¹⁺⁾
• CAS No.: 67105-75-3
• Molecular Formula: C₅₀H₆₄N₉O₁₅S₃*Na
• Molecular Weight: 1150.3
• Mol file: 67105-75-3.mol

Synonyms:

Chemical Property of C₅₀H₆₄N₉O₁₅S₃^(1-)*Na⁽¹⁺⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₆₄N₉O₁₅S₃^(1-)*Na⁽¹⁺⁾

There total 13 articles about C₅₀H₆₄N₉O₁₅S₃^(1-)*Na⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(tert-butoxycarbonyl)-D-tyrosine (70642-86-3) → C50H64N9O15S3(1-)*Na(1+) (67105-75-3,138432-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / dicyclohexylcarbodiimide / dioxane / 7 - 8 °C

2: 440 mg / Et₃N / dimethylformamide / 72 h / 7 - 8 °C

3: 1.) pyridine-sulfur trioxide, 2.) sodium carbonate / 1.) pyridine, 7 - 8 deg C, 2 d, 2.) H₂O, 30 min

With sulfur trioxide pyridine complex; sodium carbonate; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.959

Reference yield:

Boc-D-Tyr-OSu (102255-97-0) → C50H64N9O15S3(1-)*Na(1+) (67105-75-3,138432-04-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 440 mg / Et₃N / dimethylformamide / 72 h / 7 - 8 °C

2: 1.) pyridine-sulfur trioxide, 2.) sodium carbonate / 1.) pyridine, 7 - 8 deg C, 2 d, 2.) H₂O, 30 min

With sulfur trioxide pyridine complex; sodium carbonate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.36.959

Reference yield:

C54H68N10O14S2 → Boc-Tyr(SO3Na)-Met-Gly-Trp-Met-Asp-Phe-NH2 (Boc-CCK-7) (67105-75-3)

Guidance literature:

With pyridine; sulfur trioxide; In N,N-dimethyl-formamide; for 48h; Ambient temperature;

DOI:10.1135/cccc19932761

upstream raw materials:

Boc-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH₂

N-tert-butoxycarbonyl-L-methionine

N-tert-butoxycarbonyl-L-phenylalanine

H-Met-Gly-Trp-Met-Asp-Phe-NH₂ (CCK-6)

Downstream raw materials:

H-D-Tyr(SO₃H)-Met-Gly-Trp-Met-Asp-Phe-NH₂ sodium salt

Refernces

• 1、 Iuchi,Nitta,Ito,Morimoto,Tsukamoto. "Synthesis and analgesic activity of cholecystokinin-heptapeptide analogs with N-terminal substitution". . p. 959 - 965. Retrieved 2007/10/02.