(R)-3-[1-(3-fluorophenyl)cycloheptanecarbonyloxy]-1-(5-phenyl[1,3,4]oxadiazol-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride

Base Information

• Chemical Name: (R)-3-[1-(3-fluorophenyl)cycloheptanecarbonyloxy]-1-(5-phenyl[1,3,4]oxadiazol-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride
• CAS No.: 1195983-08-4
• Molecular Formula: C₃₀H₃₅FN₃O₃*Cl
• Molecular Weight: 540.078
• Mol file: 1195983-08-4.mol

Synonyms:

Chemical Property of (R)-3-[1-(3-fluorophenyl)cycloheptanecarbonyloxy]-1-(5-phenyl[1,3,4]oxadiazol-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-[1-(3-fluorophenyl)cycloheptanecarbonyloxy]-1-(5-phenyl[1,3,4]oxadiazol-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride

There total 5 articles about (R)-3-[1-(3-fluorophenyl)cycloheptanecarbonyloxy]-1-(5-phenyl[1,3,4]oxadiazol-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-fluoro-phenyl)-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (1194737-27-3) + 2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole (33575-83-6) → (R)-3-[1-(3-fluorophenyl)cycloheptanecarbonyloxy]-1-(5-phenyl[1,3,4]oxadiazol-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride (1195983-08-4)

Guidance literature:

In acetonitrile;

Reference yield:

2-but-3-enyl-2-(3-fluoro-phenyl)-hex-5-enoic acid methyl ester (1194737-20-6) → (R)-3-[1-(3-fluorophenyl)cycloheptanecarbonyloxy]-1-(5-phenyl[1,3,4]oxadiazol-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride (1195983-08-4)

Guidance literature:

Multi-step reaction with 4 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 h / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / methanol / 3040.2 Torr

3: sodium hydride / toluene / 8 h / Reflux

4: acetonitrile

With hydrogen; sodium hydride; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

methyl (3-fluorophenyl)acetate (64123-77-9) → (R)-3-[1-(3-fluorophenyl)cycloheptanecarbonyloxy]-1-(5-phenyl[1,3,4]oxadiazol-2-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride (1195983-08-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 h / Inert atmosphere; Reflux

3.1: hydrogen / palladium on activated charcoal / methanol / 3040.2 Torr

4.1: sodium hydride / toluene / 8 h / Reflux

5.1: acetonitrile

With hydrogen; sodium hydride; lithium hexamethyldisilazane; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

upstream raw materials:

1-(3-fluoro-phenyl)-cycloheptanecarboxylic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester

2-(chloromethyl)-5-phenyl-1,3,4-oxadiazole

1-(3-fluoro-phenyl)-cyclohept-4-ene carboxylic acid methyl ester

1-(3-Fluoro-phenyl)-cycloheptanecarboxylic acid methyl ester