o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

Base Information

Chemical Name:o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide
CAS No.:78221-67-7
Molecular Formula:C₆₀H₈₆N₁₂O₁₃S₂
Molecular Weight:1247.55
Hs Code.:

o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

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Chemical Property of o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

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Technology Process of o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

There total 11 articles about o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2002-44-0
melanostatin

: 78221-67-7
o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

2: HBr / acetic acid / 0.5 h / Ambient temperature

3: 2.56 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

4: HCl / dimethylformamide; diethyl ether / 0.08 h / Ambient temperature

5: 1.8 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

6: HCl / diethyl ether; dimethylformamide / 0.07 h

7: 1 g / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

8: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

9: 0.53 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In diethyl ether; acetic acid; N,N-dimethyl-formamide;
DOI:10.1135/cccc19810286

Reference yield:

: 78221-55-3
S-(2,4,6-trimethylbenzyl)-L-cysteine

: 78221-67-7
o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

Guidance literature:: Multi-step reaction with 10 steps

1: 69 percent / NaOH / H₂O / 0.5 h / Ambient temperature

2: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

3: HBr / acetic acid / 0.5 h / Ambient temperature

4: 2.56 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

5: HCl / dimethylformamide; diethyl ether / 0.08 h / Ambient temperature

6: 1.8 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

7: HCl / diethyl ether; dimethylformamide / 0.07 h

8: 1 g / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

9: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

10: 0.53 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; hydrogen bromide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1135/cccc19810286

Reference yield:

: 1585-16-6
2-chloromethyl-1,3,5-trimethylbenzene

: 78221-67-7
o-nitrobenzenesulfenyl-O-tert-butyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-(2,4,6-trimethylbenzyl)-L-cysteinyl-L-prolyl-L-leucyl-glycine amide

Guidance literature:: Multi-step reaction with 11 steps

1: 1) Na, liquid NH₃ / 1) 15 min; 2) 2 h

2: 69 percent / NaOH / H₂O / 0.5 h / Ambient temperature

3: 86 percent / dicyclohexylcarbodiimide, hydroxybenzotriazole / dimethylformamide / 1) 0 deg C, 1 h; 2) room temp., 20 h

4: HBr / acetic acid / 0.5 h / Ambient temperature

5: 2.56 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

6: HCl / dimethylformamide; diethyl ether / 0.08 h / Ambient temperature

7: 1.8 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

8: HCl / diethyl ether; dimethylformamide / 0.07 h

9: 1 g / N-ethylpiperidine / dimethylformamide / 72 h / Ambient temperature

10: HCl / dimethylformamide; diethyl ether / 0.07 h / Ambient temperature

11: 0.53 g / N-ethylpiperidine / dimethylformamide / 48 h / Ambient temperature

With 1-ethyl-piperidine; hydrogenchloride; sodium hydroxide; ammonia; hydrogen bromide; sodium; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In diethyl ether; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1135/cccc19810286