(R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-5-ethyl-heptanoic acid ethyl ester

Base Information

• Chemical Name: (R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-5-ethyl-heptanoic acid ethyl ester
• CAS No.: 99212-60-9
• Molecular Formula: C₂₉H₃₈N₂O₆
• Molecular Weight: 510.631
• Mol file: 99212-60-9.mol

Synonyms:

Chemical Property of (R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-5-ethyl-heptanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-5-ethyl-heptanoic acid ethyl ester

There total 2 articles about (R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-5-ethyl-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

ethyl 5-methyl-2-oxohexanoate (26395-03-9) + benzyl (S)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (105593-54-2) → (R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-5-ethyl-heptanoic acid ethyl ester (99212-60-9) + (S)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-5-ethyl-heptanoic acid ethyl ester (99212-62-1)

Guidance literature:

With 4 A molecular sieve; sodium cyanoborohydride; In ethanol; acetic acid; Ambient temperature;

DOI:10.1248/cpb.34.1128

Reference yield:

ethyl isocaproate (25415-67-2) → (R)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-5-ethyl-heptanoic acid ethyl ester (99212-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaOEt; 2) H₂SO₄, NaCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h

2: 9.5 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

With 4 A molecular sieve; sulfuric acid; sodium ethanolate; sodium cyanoborohydride; sodium chloride; In ethanol; acetic acid;

DOI:10.1248/cpb.34.1128

upstream raw materials:

ethyl 5-methyl-2-oxohexanoate

benzyl (S)-3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate

ethyl isocaproate