(2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane

Base Information

• Chemical Name: (2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane
• CAS No.: 1403557-35-6
• Molecular Formula: C₁₆H₃₁P
• Molecular Weight: 254.396
• Mol file: 1403557-35-6.mol

Synonyms:

Chemical Property of (2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane

There total 1 articles about (2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3S,6S)-3,6-dihydroxy-2,7-dimethyloctane cyclic sulfate (136705-68-5) + cyclohexylphosphine (822-68-4) → (2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane (1403557-35-6)

Guidance literature:

cyclohexylphosphine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 1h; Inert atmosphere; Glovebox;

(3S,6S)-3,6-dihydroxy-2,7-dimethyloctane cyclic sulfate; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 4h; Inert atmosphere;

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 23 ℃; Inert atmosphere;

DOI:10.1021/om3008772

Reference yield:

borane-THF (14044-65-6) + (2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane (1403557-35-6) → [(2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane]BH3

Guidance literature:

In tetrahydrofuran; hexane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/om3008772

Reference yield:

di(rhodium)tetracarbonyl dichloride + (2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane (1403557-35-6) → trans-[RhCl(CO)((2R,5R)-1-cyclohexyl-2,5-diisopropylphospholane)2]

Guidance literature:

In dichloromethane; Inert atmosphere;

DOI:10.1021/om3008772

upstream raw materials:

(3S,6S)-3,6-dihydroxy-2,7-dimethyloctane cyclic sulfate

cyclohexylphosphine