4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Base Information

Chemical Name:4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester
CAS No.:183005-10-9
Molecular Formula:C₃₆H₄₈N₂O₁₁Si
Molecular Weight:712.869
Hs Code.:

4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

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Chemical Property of 4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

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Technology Process of 4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

There total 12 articles about 4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 183005-10-9
4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 7 percent / Tl(NO₃)3*3H₂O, conc. HNO₃ / 1,2-dimethoxy-ethane / 28 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 2.5 h / Ambient temperature

3: aq. NaHCO₃, KI₃ / CH₂Cl₂ / 0.03 h

4: 1.) SnCl₂, 2.) AgOAc, aq. p-TsOH / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) THF, 13 h

With potassium triiodide; hydrogen; nitric acid; silver(I) acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; thallium(III) nitrate; tin(ll) chloride; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1039/p19960002079

Reference yield:

: 62916-29-4
4-acetyl-3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2-carboxylic acid benzyl ester

: 183005-10-9
4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 7 percent / Tl(NO₃)3*3H₂O, conc. HNO₃ / 1,2-dimethoxy-ethane / 28 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 2.5 h / Ambient temperature

3: aq. NaHCO₃, KI₃ / CH₂Cl₂ / 0.03 h

4: 1.) SnCl₂, 2.) AgOAc, aq. p-TsOH / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) THF, 13 h

With potassium triiodide; hydrogen; nitric acid; silver(I) acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; thallium(III) nitrate; tin(ll) chloride; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1039/p19960002079

Reference yield:

: 53365-81-4
3-(2-methoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid 2-benzyl ester

: 183005-10-9
4-(2-Methoxycarbonyl-ethyl)-5-[4-(2-methoxycarbonyl-ethyl)-2-methyl-5-oxo-3-(2-trimethylsilanyl-ethoxycarbonylmethyl)-2,5-dihydro-1H-pyrrol-2-ylmethyl]-3-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: aq. NaHCO₃, KI₃ / 1,2-dichloro-ethane / 0.5 h / Heating

2: 1.) 57percent aq. HI, Ac₂O, 50percent aq. H₃PO₂ / 1.) 0 deg C, 5 min, 2.) 0 deg C, 20 min

3: (COCl)2, DMF / CH₂Cl₂ / 0.5 h / Ambient temperature

4: DMAP / CH₂Cl₂ / 0.33 h / Ambient temperature

5: 98 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 2.5 h / Ambient temperature

6: aq. NaHCO₃, KI₃ / CH₂Cl₂ / 0.03 h

7: 1.) SnCl₂, 2.) AgOAc, aq. p-TsOH / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) THF, 13 h

With dmap; oxalyl dichloride; potassium triiodide; hydrogen iodide; hydrogen; silver(I) acetate; hypophosphorous acid; acetic anhydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; tin(ll) chloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1039/p19960002079