53365-81-4

Upstream product

• 53365-80-3 Methyl 2-(benzyloxycarbonyl)-4-(tert-butoxycarbonyl)-5-methylpyrrole-3-propionate 
• 74839-04-6 2-[(E)-Hydroxyimino]-3-oxo-hexanedioic acid 1-benzyl ester 6-methyl ester 
• 53314-75-3 Benzyl-δ-(methoxycarbonyl)-γ-oxovalerate 

Downstream Products

• 183005-13-2 4-Iodo-3-(2-methoxycarbonyl-ethyl)-5-methyl-1H-pyrrole-2-carboxylic acid benzyl ester 
• 135129-41-8 (S)-3-[(3R,4R,5R)-4,5-((R)-Benzylidenedioxy)-2-oxotetrahydropyran-3-yloxycarbonylmethyl]-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-9-(2,2,2-... 
• 183005-26-7 (R)-3-[(3R,4R,5R)-4,5-((R)-Benzylidenedioxy)-2-oxotetrahydropyran-3-yloxycarbonylmethyl]-4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-9-(2,2,2-... 
• 135100-97-9 4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-9-(2,2,2-tribromoethoxycarbonyl)-3-(2-trimethylsilylethoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one 
• 135100-96-8 4-[5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-ylmethyl]-7-carboxymethyl-2,8-bis(2-methoxycarbonylethyl)-9-(2,2,2-tribromoethoxycarbonyl)-3-(2-trimethylsilylethoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one 

Relevant academic research and scientific papers

Biosynthesis of porphyrins and related macrocycles. Part 44. Synthetic and stereochemical studies on the proposed spiro intermediate for biosynthesis of the natural porphyrins

A route is devised for synthesis of both enantiomers of the spiro lactam 4. The enzyme uroporphyrinogen III synthase (cosynthetase), which converts hydroxymethylbilane 1 into uroporphyrinogen III 3, is competitively inhibited more than twenty times more s