5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester

Base Information

Chemical Name:5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester
CAS No.:213838-36-9
Molecular Formula:C₃₀H₃₄ClNO₁₃S
Molecular Weight:684.118
Hs Code.:

5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester

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Chemical Property of 5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester

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Technology Process of 5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester

There total 4 articles about 5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 213838-32-5
N-(2',3',4',6'-tetra-O-acetyl-β-D-glucopyranosyl)-4-(4-chlorophenyl)-2,2-diethoxycarbonyl-4-oxo-2-thiobutanamide

: 213838-36-9
5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester

Guidance literature:: With phosphoric acid; acetic anhydride; for 10h; Ambient temperature;
DOI:10.1016/S0957-4166(98)00243-2

Reference yield:

: 14152-97-7
2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl isothiocyanate

: 213838-36-9
5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 30 deg C

2: 67 percent / H₃PO₄, Ac₂O / 10 h / Ambient temperature

With phosphoric acid; acetic anhydride; sodium hydride;
DOI:10.1016/S0957-4166(98)00243-2

Reference yield:

: 105-53-3
diethyl malonate

: 213838-36-9
5-(4-Chloro-phenyl)-2-thioxo-1-((2R,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyrrole-3,3-dicarboxylic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 30 deg C, 30 min

2: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 30 deg C

3: 67 percent / H₃PO₄, Ac₂O / 10 h / Ambient temperature

With phosphoric acid; acetic anhydride; sodium hydride;
DOI:10.1016/S0957-4166(98)00243-2