1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid

Base Information

Chemical Name:1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid
CAS No.:2139348-63-1
Molecular Formula:C₂₆H₃₅N₃O₁₁
Molecular Weight:565.577
Hs Code.:

Synonyms:

Suppliers and Price of 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
Pomalidomide4'-PEG5-acid ≥95%(HPLC)
25
$ 269.00

Iris Biotech GmbH
Pomalidomide-PEG5-COOH
50 mg
$ 594.00

Total 8 raw suppliers

Chemical Property of 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid

Chemical Property:

Boiling Point:791.0±60.0 °C(Predicted)
Density:1.360±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Pomalidomide4'-PEG5-acid ≥95%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Protein degrader builiding block Pomalidomide-PEG5-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Process of 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid

There total 5 articles about 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: tert-butyl 3-[2-[2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

: 2139348-63-1
1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid

Guidance literature:: With formic acid; at 20 ℃;

Reference yield: 98.0%

: 2139348-63-1
1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 1446282-18-3,872340-65-3
tert-butyl 1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate

: 2139348-63-1
1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindoline-4-yl)amino)-3,6,9,12,15-pentaoxa-18-octadecanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 2 h / 110 °C / Inert atmosphere; Microwave irradiation

2: formic acid / 12 h / 25 °C

With formic acid; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one;
DOI:10.1016/j.ejmech.2021.113645