(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

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Chemical Name:(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester
CAS No.:564489-40-3
Molecular Formula:C₃₅H₅₄N₆O₉
Molecular Weight:702.849
Hs Code.:

(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

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Suppliers and Price of (S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

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Chemical Property of (S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

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Technology Process of (S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

There total 10 articles about (S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 564489-31-2
2-(2-{[1-(2-{2-[3-(1,1-dimethyl-allyloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

: 564489-40-3
(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: With Cd/Pb; ammonium acetate; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1016/S0040-4020(03)00294-1

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 564489-40-3
(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 74 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 51 h / 0 - 20 °C

2: acetyl chloride / methanol / 3.5 h / 20 °C

3: 4.50 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 52 h / 0 - 20 °C

4: acetyl chloride / methanol / 3 h / 20 °C

5: 4.12 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 47 h / 0 - 20 °C

6: acetyl chloride / methanol / 4 h / 20 °C

7: 81 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 28 h / 20 °C

8: acetyl chloride / methanol / 3.5 h / 20 °C

9: 397 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 43 h / 0 - 20 °C

10: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 1.5 h / 20 °C

With Cd/Pb; ammonium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)00294-1

Reference yield:

: 34290-59-0
(S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate

: 564489-40-3
(S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-3-hydroxy-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: acetyl chloride / methanol / 3.5 h / 20 °C

2: 4.50 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 52 h / 0 - 20 °C

3: acetyl chloride / methanol / 3 h / 20 °C

4: 4.12 g / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 47 h / 0 - 20 °C

5: acetyl chloride / methanol / 4 h / 20 °C

6: 81 percent / diisopropylethylamine; HOBt; DCC / CH₂Cl₂ / 28 h / 20 °C

7: acetyl chloride / methanol / 3.5 h / 20 °C

8: 397 mg / diisopropylethylamine; HOBt; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 43 h / 0 - 20 °C

9: Cd/Pb; aq. NH₄OAc / tetrahydrofuran / 1.5 h / 20 °C

With Cd/Pb; ammonium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4020(03)00294-1