quinolactacin A₁

Base Information

• Chemical Name: quinolactacin A₁
• CAS No.: 386211-68-3
• Molecular Formula: C₁₆H₁₈N₂O₂
• Molecular Weight: 270.331
• Mol file: 386211-68-3.mol

Synonyms:

Chemical Property of quinolactacin A₁

Chemical Property:

Purity/Quality:

QuinolactacinA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Quinolactacin A is a TNFα and AChE inhibitor for proteomics research.

Technology Process of quinolactacin A₁

There total 8 articles about quinolactacin A₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-((1S,2S)-1-tert-Butoxycarbonylamino-2-methyl-butyl)-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester → quinolactacine A2 (386211-68-3,815576-68-2) + quinolactacin A1 (386211-68-3,815576-68-2)

Guidance literature:

With trifluoroacetic acid; In diethyl ether; water; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.10.001

Reference yield: 87.0%

2-((1S,2S)-1-tert-Butoxycarbonylamino-2-methyl-butyl)-1-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester → quinolactacine A2 (386211-68-3,815576-68-2) + quinolactacin A1 (386211-68-3,815576-68-2)

Guidance literature:

With trifluoroacetic acid; In diethyl ether; water; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.10.001

Reference yield: 85.0%

(3S,1'S)-(1'-methylpropyl)-4-methyl-1,9-dioxo-1,3,4,9-tetrahydropyrrolo[3,4-b]quinoline-2-carboxylic acid tert-butyl ester → quinolactacine A2 (386211-68-3,815576-68-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jo020746a

upstream raw materials:

(4S,5S)-ethyl 4-((tert-butoxycarbonyl)amino)-5-methyl-3-oxo-heptanoate

(3S,1'S)-(1'-methylpropyl)-4-methyl-9-oxo-1,3,4,9-tetrahydropyrrolo[3,4-b]quinoline-2-carboxylic acid tert-butyl ester

L-isoleucine

L-kynurenine