1-phenyl-8<1'-(p-chlorophenyl)ethyl>-1,8-diazaspiro<4,5>decanone-4

Base Information

Chemical Name:1-phenyl-8<1'-(p-chlorophenyl)ethyl>-1,8-diazaspiro<4,5>decanone-4
CAS No.:79139-52-9
Molecular Formula:C₂₂H₂₅ClN₂O
Molecular Weight:368.906
Hs Code.:

Synonyms:

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Chemical Property of 1-phenyl-8<1'-(p-chlorophenyl)ethyl>-1,8-diazaspiro<4,5>decanone-4

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Technology Process of 1-phenyl-8<1'-(p-chlorophenyl)ethyl>-1,8-diazaspiro<4,5>decanone-4

There total 11 articles about 1-phenyl-8<1'-(p-chlorophenyl)ethyl>-1,8-diazaspiro<4,5>decanone-4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 79139-52-9
1-phenyl-8<1'-(p-chlorophenyl)ethyl>-1,8-diazaspiro<4,5>decanone-4

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / H₂O; acetic acid / 24 h / 25 °C

2: 1.) concentrated sulfuric acid / 1.) 70 deg C; 2.) hexamethylphosphoric triamide, 20 deg C, 24 h

3: 90 percent / 5 h / Heating

4: 45 percent / sodium hydride, ethanol / toluene / 24 h / Heating

5: 80 percent / diethyl ether / 6 h

6: 1.) 70percent Redal; 2.) 4 N hydrochloric acid / 1.) benzene, reflux, 3 h 2.) water, 50 deg C, 1 h

7: 85 percent / hydrogen, hydrochlorid acid / 10percent palladium on carbon / propan-2-ol; H₂O / 40 °C

8: sodium carbonate, potassium iodide / various solvent(s) / Heating

With hydrogenchloride; ethanol; sulfuric acid; hydrogen; sodium hydride; sodium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide; palladium on activated charcoal; In diethyl ether; water; acetic acid; isopropyl alcohol; toluene;

Reference yield:

: 968-86-5
1-benzyl-4-(phenylamino)piperidine-4-carbonitrile

: 79139-52-9
1-phenyl-8<1'-(p-chlorophenyl)ethyl>-1,8-diazaspiro<4,5>decanone-4

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) concentrated sulfuric acid / 1.) 70 deg C; 2.) hexamethylphosphoric triamide, 20 deg C, 24 h

2: 90 percent / 5 h / Heating

3: 45 percent / sodium hydride, ethanol / toluene / 24 h / Heating

4: 80 percent / diethyl ether / 6 h

5: 1.) 70percent Redal; 2.) 4 N hydrochloric acid / 1.) benzene, reflux, 3 h 2.) water, 50 deg C, 1 h

6: 85 percent / hydrogen, hydrochlorid acid / 10percent palladium on carbon / propan-2-ol; H₂O / 40 °C

7: sodium carbonate, potassium iodide / various solvent(s) / Heating

With hydrogenchloride; ethanol; sulfuric acid; hydrogen; sodium hydride; sodium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide; palladium on activated charcoal; In diethyl ether; water; isopropyl alcohol; toluene;

Reference yield:

: 63260-82-2
ethyl 1-benzyl-4-phenylamino-4-piperidinecarboxylate

: 79139-52-9
1-phenyl-8<1'-(p-chlorophenyl)ethyl>-1,8-diazaspiro<4,5>decanone-4

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / 5 h / Heating

2: 45 percent / sodium hydride, ethanol / toluene / 24 h / Heating

3: 80 percent / diethyl ether / 6 h

4: 1.) 70percent Redal; 2.) 4 N hydrochloric acid / 1.) benzene, reflux, 3 h 2.) water, 50 deg C, 1 h

5: 85 percent / hydrogen, hydrochlorid acid / 10percent palladium on carbon / propan-2-ol; H₂O / 40 °C

6: sodium carbonate, potassium iodide / various solvent(s) / Heating

With hydrogenchloride; ethanol; hydrogen; sodium hydride; sodium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide; palladium on activated charcoal; In diethyl ether; water; isopropyl alcohol; toluene;