63260-82-2

Basic information

• Product Name: ethyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate
• Synonyms: ethyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate;4-(Phenylamino)-1-(phenylmethyl)-4-piperidinecarboxylic acid ethyl ester
• CAS NO: 63260-82-2
• Molecular Formula: C₂₁H₂₆N₂O₂
• Molecular Weight: 338.44334
• EINECS: 264-054-9
• Mol File: 63260-82-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 462.7°C at 760 mmHg
• Flash Point: 233.6°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 9.69E-09mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: ethyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate(63260-82-2)
• EPA Substance Registry System: ethyl 1-benzyl-4-(phenylamino)piperidine-4-carboxylate(63260-82-2)

Safety Data

• Hazardous Substances Data: 63260-82-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H26N2O2/c1-2-25-20(24)21(22-19-11-7-4-8-12-19)13-15-23(16-14-21)17-18-9-5-3-6-10-18/h3-12,22H,2,13-17H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 85098-64-2 1-benzyl-4-(phenylamino)piperidine-4-carboxylic acid 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 62-53-3 aniline 
• 968-86-5 1-benzyl-4-(phenylamino)piperidine-4-carbonitrile 
• 1096-03-3 1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide 
• 64-17-5 ethanol 

Downstream Products

• 61086-04-2 4-(N-phenylamino)-1-phenylmethyl-4-piperidinylmethanol 
• 120022-21-1 4-(Acetoxymethyl)-4-acetanilidopiperidine 
• 119997-26-1 N-Benzyl-4-<<(trimethylsilyl)oxy>methyl>-4-anilinopiperidine 
• 119997-27-2 N-Benzyl-4-(acetoxymethyl)-4-anilinopiperidine 
• 119997-31-8 Carbonic acid 1-benzyl-4-phenylamino-piperidin-4-ylmethyl ester methyl ester 
• 119997-24-9 N-Benzyl-4-(acetoxymethyl)-4-acetanilidopiperidine 
• 119997-30-7 N-Benzyl-4-<<(imidazolylcarbonyl)oxy>methyl>-4-anilinopiperidine 
• 119997-28-3 N-Benzyl-4-(acetoxymethyl)-4-propananilidopiperidine 

Relevant articles and documents

MUSCARINIC MODULATORS

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.

Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines

A new class of piperidine derivatives is added to the increasing family of compounds related to fentanyl and carfentanil. Herein, we describe the synthesis and pharmacology of a number of 1-(arylethyl)-4-(acylamino)-4-[(acyloxy)-methyl]piperidines such as 9, 15, and 23. As expected, many of these congeners of fentanyl are extremely potent narcotic agonists. The aim of the study was to identify short-acting analgesic agents (i.e. less than 6 min in the mouse hot-plate assay) for possible use in the surgical theater. Many of the drugs proved to be of intermediate and long duration (i.e. 6-15 min and > 15 min, respectively). In addition to analgesic activity, many of the compounds exhibited anesthetic properties as well. The structure-activity relationship for these entities is presented and discussed.

N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides

Novel N-aryl-N-(1-L-4-piperidinyl)arylacetamides useful as anti-arrhythmic agents, a method of treating arrhythmia which comprises the systemic administration of such compounds to warm-blooded animals and pharmaceutical compositions to be used therefor.