2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine

Base Information

Chemical Name:2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine
CAS No.:102493-73-2
Molecular Formula:C₁₈H₂₁ClN₂
Molecular Weight:300.831
Hs Code.:

Synonyms:

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Chemical Property of 2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine

Chemical Property:

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Technology Process of 2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine

There total 7 articles about 2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 102493-72-1
N-benzyl-4-chloro-5-(2-nitropropen-1-yl)-2,3-dihydroindole

: 102493-73-2
2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 2h; Heating;
DOI:10.1021/jm00158a015

Reference yield:

: 41910-64-9
4-chloroindoline

: 102493-73-2
2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / K₂CO₃, KI / dimethylformamide / 100 °C

2: 98 percent / POCl₃ / H₂O / 2 h / 100 °C

3: 81 percent / ammonium acetate / ethanol / 7 h / Heating

4: LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h / Heating

With ammonium acetate; lithium aluminium tetrahydride; potassium carbonate; potassium iodide; trichlorophosphate; In tetrahydrofuran; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00158a015

Reference yield:

: 83-42-1
6-chloro-2-nitrotoluene

: 102493-73-2
2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine

Guidance literature:: Multi-step reaction with 7 steps

1: 71 percent / KOH / ethanol; dimethylsulfoxide / 72 h / Ambient temperature

2: 98 percent / Na₂S*9H₂O, sulfur / ethanol; H₂O / 4 h / Heating

3: 78 percent / 4M HCl, SOCl₂ / CHCl₃; diethyl ether / 2 h / 50 °C

4: 93 percent / K₂CO₃, KI / dimethylformamide / 100 °C

5: 98 percent / POCl₃ / H₂O / 2 h / 100 °C

6: 81 percent / ammonium acetate / ethanol / 7 h / Heating

7: LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h / Heating

With ammonium acetate; hydrogenchloride; sodium sulfide; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; sulfur; potassium iodide; trichlorophosphate; In tetrahydrofuran; diethyl ether; ethanol; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00158a015