41910-64-9

Basic information

• Product Name: 4-Chloroindoline
• Synonyms: 4-CHLORO-2,3-DIHYDRO-1H-INDOLE;4-CHLORO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE;4-CHLOROINDOLINE;BUTTPARK 120\07-96;D-3-Chlorophenylglycine;4-CHLOROINDOLINE ,99%;1H-Indole, 4-chloro-2,3-dihydro-;4-Chloroindoline 97%
• CAS NO: 41910-64-9
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.61
• EINECS: 255-586-2
• Product Categories: Indoline & Oxindole
• Mol File: 41910-64-9.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 260 °C at 760 mmHg
• Flash Point: 111 °C
• Appearance: /
• Density: 1.214 g/cm³
• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.26±0.20(Predicted)
• CAS DataBase Reference: 4-Chloroindoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloroindoline(41910-64-9)
• EPA Substance Registry System: 4-Chloroindoline(41910-64-9)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 41910-64-9(Hazardous Substances Data)

Usage

General Description

4-Chloroindoline is a chemical compound with the molecular formula C8H7ClN. It is an indoline derivative, which is a type of heterocyclic compound containing a six-membered ring containing nitrogen. 4-Chloroindoline is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in research and development for the production of various organic compounds. 4-Chloroindoline has important applications in the fields of medicinal chemistry and material science due to its unique chemical structure and reactivity. Overall, 4-Chloroindoline is a versatile and important chemical compound with various applications in different industries and fields of research.

InChI:InChI=1/C8H8ClN/c9-7-2-1-3-8-6(7)4-5-10-8/h1-3,10H,4-5H2

Upstream product

• 25235-85-2 4-chloro-1H-indole 
• 64-19-7 acetic acid 
• 20870-77-3 4-chloroindolin-2-one 
• 102493-68-5 2-(2-chloro-6-nitrophenyl)-ethanol 
• 83-42-1 6-chloro-2-nitrotoluene 
• 100376-53-2 2-(2-amino-6-chlorophenyl)ethyl alcohol 

Downstream Products

• 102493-70-9 N-benzyl-4-chloro-2,3-dihydroindole 
• 102493-71-0 N-benzyl-4-chloro-2,3-dihydroindole-5-carboxaldehyde 
• 102493-73-2 2-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-yl)-1-methyl-ethylamine 
• 102493-81-2 1-(1-Benzyl-4-chloro-2,3-dihydro-1H-indol-5-ylmethyl)-propylamine 
• 102493-72-1 N-benzyl-4-chloro-5-(2-nitropropen-1-yl)-2,3-dihydroindole 
• 102493-80-1 N-benzyl-4-chloro-5-(2-nitrobuten-1-yl)-2,3-dihydroindole 
• 1620581-31-8 2-(5-((4-chloroindolin-1-yl)sulfonyl)-2-methoxyphenyl)-2-isobutyl-4-methylpentanenitrile 
• 885278-80-8 indoline-4-carbonitrile 
• 25235-85-2 4-chloro-1H-indole 

Relevant articles and documents

Synthesis and Photophysical Study of Heteropolycyclic and Carbazole Motif: Nickel-Catalyzed Chelate-Assisted Cascade C-H Activations/Annulations

Herein, nickel-catalyzed synthesis of polyarylcarbazole through sequential C-H bond activations has been described. Regioselective indole C2/C3 functionalization has been achieved in the presence of indole C7-H, which is quite challenging. In addition, this approach also gives easy access to building a heteropolycyclic motif through C6/C7 C-H functionalization of indoline. This methodology is not limited to aromatic internal alkynes as coupling partners; aliphatic alkynes have also shown good tolerance. Notably, during the optimization the catalytic enhancement with sodium iodide as an additive has been observed. We have also studied the photophysical properties of these highly conjugated molecules.

Sustainable Radical Cascades to Synthesize Difluoroalkylated Pyrrolo[1,2-a]indoles

We disclose herein a photocatalytic difluoroalkylation and cyclization cascade reaction of N-(but-2-enoyl)indoles with broad substrate scopes in up to 90% isolated yield. This method provides sustainable and efficient access to synthesize difluoroalkylated pyrrolo[1,2-a]indoles with a quaternary carbon center under mild conditions.

NOVEL P2X7R ANTAGONISTS AND THEIR USE

The present application is directed to novel P2X7R antagonists that are N- indol-3-yl-acetamide and N-azaindol-3-yl-acetamide compounds, pharmaceutical compositions comprising the same and their use for the prophylactic or therapeutic treatment of diseases mediated by P2X7R activity.